ABIM
ANA - correct answerSLE -- >95% sensitivity (also in SSc, Sjogren, MCTD) Anti-dsDNA - correct answerSLE -- >95% specificity, correlates with disease activity Anti-Smith - correct answerSLE -- most specific, 99%. But only 30% sensitive Anti-U1 RNP - correct answerMCTD (also in SLE) -- does not correlate with disease activity Anti-Ro (SSA) & Anti-La (SSB) - correct answerSjogren syndrome (also in SLE)-- assoc with photosensitive rash. + mother increases risk for neonatal lupus erythematosus (rash and CHB) Antiribosomal P - correct answerSLE -- assoc with CNS lupus and lupus hepatitis Anti-Scl-70 (antitopoisomerase-1) - correct answerDcSSc -- assoc with pulmonary fibrosis Anticentromere - correct answerLcSSc (CREST) -- increases risk for pulmonary arterial hypertension c-ANCA (antiproteinase-3) - correct answerGranulomatosis with polyangiitis (Wegener's) -- 90% sensitivity when disease is active; high specificity in classic presentations p-ANCA (antimyeloperoxidase) - correct answerMicroscopic polyangiitis, eosinophilic granulomatosis with polyangiitis (Churg-Strauss). Atypical can be seen in IBD and with positive ANA Anti-Jo-1 (Anti-aminoacyl-tRNA synthetase) - correct answerPolymyositis -- assoc with antisynthetase syndrome
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