ANCC Sample Questions and Answers

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ANCC Sample Questions and Answers | Latest Version | 2025/2026 | Correct & Verified

A 28-year-old patient with schizophrenia has been stable on risperidone but develops gynecomastia. What is the best next step?

• Increase the dose of risperidone

✔✔B. Switch to aripiprazole

• Add benztropine
• Discontinue all medications

Which laboratory test should be obtained prior to initiating lithium therapy?✔✔A. Thyroid stimulating hormone

• Creatine phosphokinase
• Hemoglobin A1c
• Vitamin B12

A patient with major depressive disorder reports no improvement after 6 weeks on sertraline 50 mg. What is the most appropriate next step? 1 / 3

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• Discontinue the medication and start psychotherapy
• Add bupropion

✔✔C. Increase the dose of sertraline

• Switch to a tricyclic antidepressant

A patient taking clozapine reports flu-like symptoms and a sore throat. What is the priority action?✔✔A. Order a CBC with differential

• Reassure the patient and monitor symptoms
• Increase fluid intake
• Decrease the dose of clozapine

A 15-year-old presents with poor concentration, hyperactivity, and impulsivity. What is the most likely diagnosis?

• Conduct disorder

✔✔B. Attention-deficit/hyperactivity disorder

• Oppositional defiant disorder
• Autism spectrum disorder 2 / 3

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Which medication requires routine monitoring of liver enzymes?

• Lithium
• Aripiprazole

✔✔C. Valproic acid

• Fluoxetine

A PMHNP is evaluating a patient with suspected alcohol use disorder. Which screening tool is most appropriate?

✔✔A. AUDIT

B. PHQ-9

C. GAD-7

D. MMSE

Which personality disorder is characterized by unstable relationships, emotional lability, and fear of abandonment?

• Antisocial personality disorder

✔✔B. Borderline personality disorder

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