ASCP MLT EXAM PRACTICE AND STUDY GUIDE

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ASCP MLT EXAM/ PRACTICE AND STUDY GUIDE

EXAM NEWEST 2025/2026 TEST BANK| COMPLETE

QUESTIONS AND CORRECT DETAILED ANSWERS

(VERIFIED ANSWERS) ALREADY GRADED A+| ASCP

MLT EXAM PREP 2025|| BRAND NEW!!

Which of the following organs is responsible for the maturation of T lymphocytes and regulation of their expression of CD4 and CD8?

• Spleen
• Liver
• Thymus
• Bone marrow - Correct Answer - c. Thymus

The best source of active bone marrow from a 20-year-old would be:

• Iliac crest
• Femur
• Distal radius
• Tibia - Correct Answer - a. Iliac crest

Physiologic programmed cell death is termed:

• Angiogenesis
• Apoptosis
• Aneurysm 1 / 4

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• Apohematics - Correct Answer - b. Apoptosis

Which organ is the site of sequestration of platelets?

• Liver
• Thymus
• Spleen
• Bone marrow - Correct Answer - c. Spleen

Which one of the following cells is a product of the CLP?

• Megakaryocyte
• T lymphocyte
• Erythrocyte
• Granulocyte - Correct Answer - b. T lymphocyte

What growth factor is produced in the kidneys and is used to treat anemia associated with kidney disease?

• EPO
• TPO
• G-CSF
• KIT ligand - Correct Answer - a. EPO

Which one of the following cytokines is required very early in the differentiation of a hematopoietic stem cell?

• IL-2 2 / 4

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• IL-8
• EPO
• FLT3 ligand - Correct Answer - d. FLT3 ligand

Hematopoietic stem cells produce all lineages of blood cells in sufficient

quantities over the lifetime of an individual because they:

• Are unipotent
• Have the ability of self-renewal by asymmetric division
• Are present in large numbers in the bone marrow niches
• Have a low mitotic potential in response to growth factors - Correct

Answer - b. Have the ability of self-renewal by asymmetric division

Which of the following is an erythrocyte progenitor?

• Pronormoblast
• Reticulocyte
• CFU-E
• Orthochromic normoblast - Correct Answer - c. CFU-E

Which of the following is the most mature normoblast?

• Orthochromic normoblast
• Basophilic normoblast
• Pronormoblast
• Polychromatic normoblast - Correct Answer - a. Orthochromic

normoblast 3 / 4

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pg. 4 Which of the following is not related to the effects of erythropoietin?

• The number of divisions of a normoblast
• The formation of pores in sinusoidal endothelial cells for marrow

egress

• The time between mitoses of normoblasts
• The production of antiapoptotic molecules by erthroid progenitors -

Correct Answer - b. The formation of pores in sinusoidal endothelial cells for marrow egress

Hypoxia stimulates RBC production by:

• Inducing more pluripotent stem cells into erythroid lineage
• Stimulating EPO production by the kidney
• Increasing the number of RBC mitoses
• Stimulating the production of fibronectin by macrophages of the bone

marrow - Correct Answer - b. Stimulating EPO production by the kidney

In the bone marrow, RBC precursors are located:

• In the center of the hematopoietic cords
• Adjacent to megakaryocytes along the adventitial cell lining
• Surrounding fat cells in apoptotic islands
• Surrounding macrophages in erythroid islands - Correct Answer - d.

Surrounding macrophages in erythroid islands

What single feature of normal RBCs is most responsible for limiting their life span?

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