BCH210 Exam Study Guide Questions with Correct Verified

pg. 1 BCH210 Exam/ Study Guide Questions with Correct Verified Answers – Latest Update 2024/ Rated A+

Which AA likes to form alpha helix? - ANSWER - Glutamate

Which AA likes to form beta sheet - ANSWER – Valine

which amino acids have aromatic side chains? - ANSWER - phenylalanine, tyrosine, tryptophan

which amino acids are sulfur containing? - ANSWER - cysteine and methionine

acidic amino acids? - ANSWER - asparagine, glutamine, aspartate, glutamate

• basic amino acids - ANSWER - lysine, arginine, histidine,

Which amino acids have aliphatic side chains? - ANSWER - alanine, glycine, valine, leucine, isoleucine,

which amino acids have aliphatic hydroxyl side chains? - ANSWER - serine and threonine

hydrophobic amino acids - ANSWER - alanine, glycine*, valine, isoleucine, leucine, phenylalanine, methionine, proline

hydrophilic amino acids POLAR - ANSWER - asparagine, glutamine, serine, threonine, cysteine*

hydrophilic amino acids CHARGED - ANSWER - arginine, lysine, histidine (basic), aspartic acid, glutamic acid

Amphipathic aromatic amino acids - ANSWER - tryptophan, tyrosine 1 / 4

pg. 2

Alpha Helix- N-H residue and C=O - ANSWER - N-H group of residue i donates a H-bond back to the C=O group of residue i-4

Features of the alpha helix:

• residues p/turn
• degrees between adjacent residues
• rise p/residue
• how many Å across backbone?
• inter/intrastrand bonds? - ANSWER - a) 3.6
• 100
• 1.5
• 5
• intrastrand

In other words, there's a....of secondary structures into a define protein...... - ANSWER - - condensed

• tertiary (3°)
• (one polypeptide chain)
• might be final structure
• folding
• motifs and domains

If you have multiple chains coming together, you have a.....structure (assembly of......into.....structures) - ANSWER - - quaternary (4°)

• distinct chains
• multi-subunit

AAs are joined....in a......rxn. That rxn is.....and we lose....., which is why it's called a......rxn. - ANSWER - - enzymatically, condensation

• COOH + NH3+ -> peptide bond (O=C - N-H) 2 / 4

pg. 3

• 1 H2O molecule - 1 OH + 1H+ (might be 2 Hs on N, depending on protonation state)
• condensation rxn

There are certain....of rotation allowed (can generate the..... plot) , ranging from....to.... - ANSWER - - angles

• Ramanchandran
• -180 to +180 (????)

There are only certain angles allowed in polypeptide bond rotations (some are not.....) because it can create....The preferred configuration is..... to.......because a lot of our side chains are very......that's better to be.....from each other (gives you a more......) - ANSWER - - permitted

• steric clashes
• trans
• minimize steric clashes
• bulky (Y, W etc)
• kept away
• extended structure

The...configuration can be allowed if the....want to interact - ANSWER - - cis

• two side chains

Which of the following AAs have the biggest impact on the path of the polypeptide backbone?

• G
• H
• P

D. W - ANSWER - Answer: C - proline

pKa of Arginine side chain - ANSWER - 12.5

pKa of Lysine side chain - ANSWER - 10.5

• / 4

pg. 4 pKa of Cysteine side chain - ANSWER - 8.3

Histidine pkA side chain - ANSWER - 6

Glutamic acid pKa side chain - ANSWER - 4.3

Aspartic Acid side chain pKa - ANSWER - 3.9

The backbone of the primary structure consists of.....and...., while the variable part are the..... - ANSWER

• - peptide bonds
• alpha carbons
• distinct R side chains

You can have a zwitterion for a.....or a...., as long as the..... - ANSWER - - long polypeptide

• single AA
• net charge is neutral

A single AA is called a..... - ANSWER - residue

[SLIDE 5, unannotated]

The sequence of AA is... - ANSWER - Y-G-G-F-L

A peptide bond has.....(can....), which allows for the......of.....bond due to the...... - ANSWER - - EN atoms

• H-bond
• movement/resonance
• double
• dipole on C and O
• / 4