APHON Principles of Chemo and Biotherapy Exam Latest Update
Question: What are biotherapy or targeted anticancer agents
also known as?
CORRECT ANSWER : Biological response modifiers
(BRM)
Question: Tyrosine kinase inhibitors (TKIs) are what class?
CORRECT ANSWER : Biotherapy
Question: Monoclonal antibodies (MoAbs) are what class?
CORRECT ANSWER : Biotherapy
Question: Define pharmacokinetics
CORRECT ANSWER : Study of drug absorption,
metabolism, and excretion
Question: Define pharmacodynamics
CORRECT ANSWER : The concentration of the drug in the
body and how it produces a response
Question: Define adjuvant chemotherapy
CORRECT ANSWER : The use of chemo after another type
of therapy, such as surgery, to treat residual disease or undetectable metastasis.
Question: Define neoadjuvant chemotherapy
CORRECT ANSWER : When chemo is used preoperatively
to decrease tumor burden in order to make it easier to remove the tumor surgically.
Question: Define sanctuary sites
CORRECT ANSWER: Sites within the body where tumor
cells sequester and are not easily reached by chemo such as the CNS
Question: What normal cells are most often affected by
chemotherapy?
CORRECT ANSWER : Hematopoietic, mucosal (mouth &
GI), hair follicles
Question: Why use chemotherapy?
CORRECT ANSWER : To prevent cancer cells from
dividing, metastasizing, and ultimately causing the death of the patient
Question: What is the goal of chemotherapy in terms of cure?
CORRECT ANSWER : To permanently eradicate the cancer
Question: What is the goal of chemotherapy in terms of
control?
CORRECT ANSWER : To extend the length & QOL when
cure is not feasible or realistic
Question: What is the goal of chemotherapy in terms of
palliation?
CORRECT ANSWER : Minimize pain and suffering during
end of life
Question: What is the resting phase of the cell cycle?
CORRECT ANSWER : Gap 0 - cells not dividing
Question: What is the postmitotic phase of the cell cycle?
CORRECT ANSWER : Gap 1 - enzymes needed for DNA
synthesis are produced, protein and RNA synthesis takes place (18 Hours)
Question: What is the synthesis (S) phase of the cell cycle?
CORRECT ANSWER : Cellular DNA duplicated (20 hours)
Question: What is the premitotic phase of the cell cycle?
CORRECT ANSWER : Gap 2 - both protein and RNA
synthesis occur, precursors of mitotic spindle are produced.Shortest phase
Question: What is the mitosis (M) phase of the cell cycle?
CORRECT ANSWER : Cell division occurs in 4-step phase
(prophase, metaphase, anaphase, telophase) 1 Hour