ONS-ONCC Chemotherapy Immunotherapy Certificate Exam Latest Update 2023-2024 135 Questions and Verified Accurate Answers Ace Your First Attempt With the Best Solution -Exceptions to this are those that are (Resting in G0 phase) - Correct Answer: - Exceptions to this are those that are metabollically active, such as
-granulocytes
-and the epithelium of the GI tract
- Elimination of the Hazard: - Correct Answer: -highest level of protection from a
hazardous exposure
-substitute a less toxic substance for the hazardous material
-not feasible with drug therapy
- Phagocytes
- Natural Killer Cells
- Granulocytes
4. Macrophages - Correct Answer: 1.Cells that engulf and destroy invader
- Cells that sense receptors on self and non-self to determine if they should kill or not
- Type of WBC that have granules (Neutrophils
Eosinophils - parasites Basophils - release histamine to stimulate immune response)
- Large phagocytic cells stimulated by infection
2. Engineering Controls - Correct Answer: -second highest level of protection
-use of machines or equipment that isolate or contain the hazard to reduce worker exposure
-Examples: biosafety cabinets and closed-system drug-transfer devices
3. Administrative Controls - Correct Answer: -third level of protection
-safe handling policies
-procedures
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-work practices
-education and training of those responsible for HD handling
4. PPE - Correct Answer: -lowest form of protection
-consisting of garments that provide barriers to protect workers from HDs
-places the primary responsibility for protection on the worker
Absolute Neutrophil Count - Correct Answer: - (%segs + %bands) x (WBC) / 100
Active Immunotherapy - Correct Answer: -capitalize on the immune system's ability to remember a foreign invade
-mount an immune response against the tumor and hopefully remember the cancer cells long after treatment has stopped
-includes cancer vaccines
Adaptive Immunity - Correct Answer: -Stimulated if innate immunity is insufficient
-leads to immune system memory
-Humoral immunity
-Cell-mediated immunity
-Regulatory T-cells
Adjuvant therapy - Correct Answer: -additonal cancer treatment given after the primary treatment to lower the risk that the cancer can recur
-Examples: chemo, radiation therapy, hormone therapy, targeted therapy, or biologic therapy
Alkylating Agent Subgroups - Correct Answer: -Nitrogen mustards
(cyclophosphamide{Cytoxin}, ifosfamide{Ifex}, bendamustine{Treanda})
-Platinum-based (cisplatin{Planitol}, carboplatin{Paraplatin}): do not possess an alkyl group
-nitrosoureas
Alkylating Agents - Correct Answer: -function by causing a break in the DNA helix strand, causing interference with DNA replication, which results in cell death 2 / 3
B-Cell - Correct Answer: -each one is programmed to make one specific antibody
-Can recognize antigens whether they are freely circulating in the blood or attached to surface of a microbe
-When dividing, can become plasma cells which will then begin secreting antibodies that are unique to that antigen
BCR/ABL - Correct Answer: -fusion protein tyrosine kinase formed with a gene
translocation occurs between gene 9 and 22
-gene abnormality called the Philadelphia chromosome seen in CML and ALL
Benign Tumors - Correct Answer: -encapsulated and grow in an orderly manner with smooth edges
-Do not invade neighboring tissue
-DO not metastasize to distant sites
-the cells well differentiated in that they look like the parent cell
Can I be intimate with my partner during treatment? - Correct Answer: -you should definiely check with your HCP first to be sure
-traces of chemo may be present in vaginal fluid for up to 48 hours after treatment
-use of a barrier is recommended for this reason for at least the first 48 hours
Carboplatin (Paraplatin) - Correct Answer: -Alkylazing agent
-possibility for a hypersensitivity reaction which is rash, urticaria, erythema, pruritis, rarely bronchospasm and hypotensision
-notify RN if itching, scratchy throat, difficulty breathing, rash
-Blood count, particularly platelets, monitored because thrombocytopenia is a dose- limiting toxicity
-Oral dosage: 1-5mg/kg/day
Cell cycle video and image - Correct Answer:
http://highered.mheducation.com/sites/0072495855/student_view0/chapter2/animation_ _how_the_cell_cycle_works.html
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