NUSCTX 11- UC Berkeley Verified Multiple Choice and Conceptual Actual Exam Questions With Reviewed 100% Correct Detailed Answers Guaranteed Pass!!Current Update
- What might occur to increase the toxicity of lipophilic chemicals? -
ANSWER Bioaccumulation and Phase I
- What could be a specific way that toxicity from an oil spill is most harmful to
fish? - ANSWER Absorbs and bioaccumulates in fat, and can be metabolized into carcinogens.
- If a certain substance causes "DNA adducts" which experiments could you
try to detect it? - ANSWER Measure Phase II enzymes and hypothesize that these enzymes are inhibited Show that the chemical is a mimic for other nucleotides in DNA replication Measure chemical metabolites in milk in female animals.
- What is true about biotransformation? - ANSWER It is a 2-phase
process It can decrease toxicity It can increase toxicity, it makes compounds more hydrophilic (water soluble) 1 / 2
- What are factors in calculating toxicant risk? - ANSWER Exposure
Absorption Site of Action
- Biological factors that determine toxicity? - ANSWER Absorption
Metabolism Lipophilic character Distribution (lymph system)
- Circulatory path of lymph - ANSWER Route to fast entry into lungs and
blood
- Circulatory path of bile duct - ANSWER Breaks down lipophilic
chemicals, enterohepatic circulation
- Circulatory path of portal vein - ANSWER Routes for metabolism by CYP
in liver (gut to liver)
- TD - ANSWER Toxic Dose
- LD - ANSWER Lethal Dose
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