2024 CPPS 303 - Lipids 10 ( Glucose Lipid Related Metabolic Disorders ) Pt.2 Complete Questions & Answers (Solved) 100% Correct
- Dyslipidemia
Answer: Disrupted lipid homeostasis
- High LDL-C (low-density lipoprotein cholesterol): Bad cholesterol
- Low HDL-C (high-density lipoprotein cholesterol): Good cholesterol
- Atherogenic Dyslipidemia
Answer: abnormal levels of blood lipids that promote the development of
atherosclerosis
- Contributes to residual risks
- Overall relationships in dysregulated lipid homeostasis
Answer:
- Increased VLDL and chylomicron secretion
- Decreased clearance of fats
- Formation of small dense LDL
- Low HDL
- Accumulation of remnant lipoproteins
- Hypertriglyceridemia
Answer: Increased TG
- Post-prandial lipemia
Answer: Rise in TG after eating
- What modulates the levels of plasma TG
Answer: Multiple genes working in concert with non-genetic
secondary/environmental contributors
- Mutations in genes from non-genetic factors
Answer: Most common
- Alters TG-rich lipoprotein synthesis and catabolism
- Mutations in genes from genetic factors
Answer: More Rare
- Background predisposition
- Genetic mixed with environment
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- Normal TG levels
Answer: 0-2 mmol/L
- Mild-Moderate TG elevation levels
Answer: 2-10 mmol/L
- Increased CVD risk
- Severe TG elevation levels
Answer: e 10 mmol/L
- Chylomicronaemia
- Pancreatitis risk
- Increased CVD risk
- Metabolic Syndrome
Answer: Co-occurrence (clustering) of several known cardiovascular risk factors
- Insulin resistance
- Obesity
- Atherogenic dyslipidemia
- Hypertension
- Definition of Metabolic Syndrome
Answer: Any 3 of the 5 criteria below
- Obesity
- Hyperglycemia
- Dislipidemia (High TG)
- Dislipidemia (Low HDL cholesterol)
- Hypertension
- Central Features of metabolic syndrome (4)
Answer:
- Insulin resistance
- Visceral Obesity
- Atherogenic dyslipidemia (increase in VLDL production and decreased clearance)
- Endothelial dysfunction
- Non-Alcoholic Fatty Liver Disease (NAFLD)
Answer: An accumulation of fat in the liver of people without drinking
- inflammation and scarring in the liver
- Most common cause of chronic liver disease
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