2024 CPPS 303 - Lipids 3 ( Liver Lipid Metabolism ) Complete Questions & Answers (Solved) 100% Correct
- Synthesis and storage of bile
Answer: Synthesized in the liver
- Stored in the gallbladder
- Enterohepatic circulation of bile acids
Answer:
1) After a meal, bile will be released from the gallbladder into the duodenum
2) Majority of Bile is taken up by the enterocytes
- Only 5% of bile acids are lost through fecal output
3) Bile salts are released into the portal vein
4) Salts are released from the portal vein into the liver for recycling
- Where does passive diffusion into the enterocytes take place?
Answer: Jejunum and Colon
- of unconjugated and un charged bile acids
- Where does active uptake into the enterocytes take place?
Answer: Ileum
- of conjugated bile acids
- By bile salt transporters
- Majority of the bile acids are absorbed here
- Bile acids Escaping portal vein
Answer: Will enter systemic circulation
- The liver is able to obtain 80-90% of the extracted bile from the portal vein
- Bilary Tract
Answer: pathway for bile flow from the liver to the bile duct and into the duodenum
- Exogenous pathway of lipid absorption
Answer: Predominates after eating a high fat meal
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1) Chylomicrons from the enterocyte enter the lymph and drain into the blood stream at the superior vena cava
2) Lipoprotein Lipase (LPL) will remove the TAGs from chylomicron remnants at adipose and muscle tissues
3) The cholesterol rich chylomicron remnants ill go to the liver, where the cholesterol is stored in droplets, repackaged into VLDL or excreted in bile
- Endogenous pathway of lipid absorption
Answer: Body absorbs lipids that are pro duced by the body
- Liver during inter-digestive phase
Answer: Liver receives FAs from glycerol and adi pose tissue
- Liver during post-prandial phase
Answer: Liver will synthesize FAs and phospholipids
- Phospholipids will then be excreted into the biliary tract to establish micelles
- What does the liver synthesize/secrete?
Answer: VLDL, Cholesterol and bile acids
- What does the liver uptake?
Answer:
- Major LDL uptaker
- Chylomicrons remnant
- VLDL, IDL
- HDL Cholesterol
- Composition of VLDL
Answer:
- TAG
- Phospholipids
- Cholesterol
- Cholesteryl Esters (CE)
- Proteins (ApoB100)
- ApoB100
Answer: Apolipoprotein B100
- Structural protein that stabilizes VLDL
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