2024 CPPS 303 - Lipids 5 ( Adipose Tissues in Metabolism and as an Endocrine Organ ) Pt. 2 Complete Questions & Answers (Solved) 100% Correct
- What do Adipocytes Secrete? (8)
Answer:
- Metabolites
- Inflammatory Mediators
- Novel Signalling Lipids
- Circulating Exosomal miRNAs
- Binding proteins/precursors
- Peptides
- Hormones
- Growth Factors
- How do secreted products act on cells/organs?
Answer: Both paracrine and endocrine action
- Processes that Adipocytes regulate (4)
Answer:
- Lipid and glucose homeostasis
- Energy balance
- Inflammation
- Tissue repair
- Adipokines
Answer: Regulatory peptides secreted by adipocytes
- Lipokines
Answer: Regulatory lipid species secreted by adipocytes
- Exosomes
Answer: tiny vesicle that removes debris and transports material
- Main Adipokines (3)
Answer:
- Leptin
- Adiponectin
- Resistin 1 / 2
- Adipokines exclusively secreted directly from mouse adipocytes
Answer:
- Leptin
- Adiponectin
- Resistin
- Adipokine that isn't secreted directly from human adipocytes
Answer: Resistin
Humans
- Resistin is secreted from Adipose Tissue macrophages, not adipocytes
- What are other factors that are not exclusively secreted from adipocytes-
Answer: FGF21
- Secreted by Hepatocytes
- What can dysregulation of Leptin, Adiponectin and Resistin lead to? (3)
Answer:
- Systemic metabolic dysfunction
- Chronic metabolic diseases
- Cancer
- Leptin
Answer: A peptide hormone released exclusively from adipocytes
- What does leptin act on?
Answer:
- Brain
- Pancreas
- Cardiovascular system
- Effects of Leptin
Answer:
- Suppresses Appetite
- Promotes Energy Expenditure
- Regulates Heat Loss
- Which gene encodes Leptin
Answer: obese gene (ob)
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