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Depression HESI Questions and Answers | Latest Version | 2025/2026 | Correct & Verified
Which neurotransmitter imbalance is most often linked to depression?
- Acetylcholine
- Dopamine
- Histamine
✔✔B. Serotonin
Which symptom is most commonly reported by patients with depression?
- Hypertension
- Chest pain
- Joint stiffness
✔✔C. Persistent sadness
Which nursing intervention is most important for a severely depressed patient with suicidal thoughts?
- Encourage independence 1 / 4
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✔✔B. Ensure constant supervision
- Promote physical activity
- Discuss career goals
Which sleep disturbance is common in depression?
- Sleepwalking
- Sleep paralysis
- Night terrors
✔✔B. Early morning awakening
Which medication class is most commonly prescribed for major depressive disorder?✔✔A. Selective serotonin reuptake inhibitors (SSRIs)
- Antihistamines
- Beta-blockers
- Anticoagulants
Which statement by a patient indicates understanding of antidepressant therapy?
- “I will feel better tomorrow after my first dose.” 2 / 4
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✔✔B. “It may take several weeks before I notice improvement.”
- “I should stop taking the medication once I feel fine.”
- “I should double my dose if I forget one.”
Which physical symptom can be associated with depression?
- Improved appetite
- Increased energy
- Hypertension
✔✔B. Fatigue
Which activity should be encouraged to support recovery in depression?✔✔A. Gentle daily exercise
- Isolating for self-reflection
- Staying in bed most of the day
- Avoiding social contact
Which lab test may be ordered to rule out other causes of depressive symptoms?
- Blood glucose test 3 / 4
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✔✔B. Thyroid function test
- Cholesterol test
- Hemoglobin A1C
Which statement shows hopelessness, a hallmark of depression?
- “I’ll feel better after some rest.”
- “I should talk to my friends more often.”
- “I’ll try going for a walk tomorrow.”
✔✔C. “Nothing will ever get better for me.”
Which patient behavior suggests improvement in depression?✔✔A. Participating in group therapy sessions
- Avoiding conversations with staff
- Refusing meals
- Staying in bed all day
Which risk is highest in patients with major depression?
- Diabetes
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