Drug name Indication

NR 546 Week 3

Drug name Indication

Target symptoms: state if positive or negative effect

Potency (if noted. receptor occupancy if noted ) Neurotransmitter(s) affected Half-life (T1/2), metabolism

(CYP 450

enzyme) Notable side effects (associate to pathway or NT) Typical antipsychotics (conventional) Haloperidol Blocks dopamine 2 receptors, reducing positive symptoms of psychosis and possibly combative, explosive, and hyperactive behaviors Blocks dopamine

• receptors in the nigrostriatal pathway, improving

tics and other symptoms in Tourette’s syndrome.Decanoate half-life approximately

• weeks Oral

half-life approximately 12–38 hours Acute blockade of dopamine 2 receptors in the striatum can cause drug -induced parkinsonism, dystonia, or akathisia Chronic blockade of dopamine 2 receptors in the striatum can cause tardive dyskinesia By blocking dopamine 2 receptors in the pituitary, it can cause elevations in prolactin By blocking dopamine 2 receptors excessively in the mesocortical and mesolimbic dopamine pathways, especially at high doses, it can cause worsening of negative and cognitive symptoms (neuroleptic-induced deficit syndrome).Blocking alpha 1 adrenergic receptors can cause dizziness, hypotension, and syncope 1 / 3

Thioridazine Blocks dopamine 2 receptors, reducing positive symptoms of psychosis Metabolized by CYP450 2D6 Acute blockade of dopamine 2 receptors in the striatum can cause drug -induced parkinsonism, dystonia, or akathisia.Chronic blockade of dopamine 2 receptors in the striatum can cause tardive dyskinesia By blocking dopamine 2 receptors in the pituitary, it can cause elevations in prolactin By blocking dopamine 2 receptors excessively in the mesocortical and mesolimbic dopamine pathways, especially at high doses, it can cause worsening of negative and cognitive symptoms (neuroleptic-induced deficit syndrome) Blocking muscarinic cholinergic receptors can 2 / 3

cause dry mouth, blurred vision, urinary retention, constipation, and paralytic ileus Antihistaminic actions may cause sedation, weight gain Blocking alpha 1 adrenergic receptors can cause dizziness, hypotension, and syncope Thiothixene Blocks dopamine 2 receptors, reducing positive symptoms of psychosis Commonly prescribed for schizophrenia and bipolar disorder Initial elimination half-life approximately 3.4 hours Terminal elimination half-life approximately 34 hours Acute blockade of dopamine 2 receptors in the striatum can cause drug -induced parkinsonism, dystonia, or akathisia Chronic blockade of dopamine 2 receptors in the striatum can cause tardive dyskinesia.By blocking dopamine 2 receptors in the pituitary, it can cause elevations in prolactin By blocking dopamine 2 receptors excessively in the mesocortical and mesolimbic dopamine pathways, especially at high doses, it can cause worsening of negative and cognitive symptoms (neuroleptic-induced deficit syndrome) Blocking muscarinic cholinergic receptors can cause dry mouth, blurred vision, urinary retention, constipation, and paralytic ileus

Antihistaminic actions may cause sedation, weight gain Blocking alpha 1 adrenergic receptors can cause dizziness, hypotension, and syncope.Fluphenazine Blocks dopamine 2 receptors, reducing positive symptoms of psychosis Commonly prescribed for Bipolar disorder Mean half-life of oral formulation approximately 15 hours Mean half-life of intramuscular formulation approximately 6.8–9.6 days Acute blockade of dopamine 2 receptors in the striatum can cause drug -induced parkinsonism, dystonia, or akathisia Chronic blockade of dopamine 2 receptors in the striatum can cause tardive dyskinesia By blocking dopamine 2 receptors in the pituitary, it can cause elevations in prolactin.By blocking dopamine 2 receptors excessively in the mesocortical and mesolimbic dopamine pathways, especially at high doses, it can cause

• / 3