Exam 160 Questions with Correct Answers

ONS Chemotherapy Immunotherapy Certificate Exam 160 Questions with Correct Answers

2023/2024

3 major phases of cell division: - Correct Answer Interphase

Mitotic phase Cytokinesis

3 steps of interphase: - Correct Answer First growth phase (G1)

Synthesis phase (S phase) Second growth phase (G2)

4 phases of mitosis: - Correct Answer Prophase

Metaphase Anaphase Telophase Innate immunity: - Correct Answer Non-specific response, either:

• Barrier (skin, mucous membranes, flora of skin/gut)
• Cellular components (phagocytes, natural killer cells, granulocytes, macrophages)

Adaptive immunity: - Correct Answer Follows innate immunity if unsuccessful. Memory immunity,

including:

• Humoral immunity (production of antibodies or immunoglobulins)
• Cell mediated immunity (dependent upon T cells)
• Regulatory T -cells (prevent autoimmune reactions and limit inflammatory responses)

Define mutations - Correct Answer Variations in the nucleotide sequence of a gene

• main goals of treatment: - Correct Answer Cure 1 / 3

Control Palliation Define neoadjuvant therapy - Correct Answer Treatment is given prior to surgery to shrink the tumor Define adjuvant therapy - Correct Answer Additional cancer treatment given after the primary treatment to lower the risk that the cancer reoccur Define conditioning/preparative therapy - Correct Answer Treatments used to prepare a patient for stem cell transplantation

2 types of conditioning therapies: - Correct Answer Myeloablative

Nonmyeloablative Define dose density - Correct Answer Drug dose per unit of time Define dose intensity - Correct Answer Amount of drug delivered over time How is relative dose intensity (RDI) calculated? - Correct Answer By comparing the dose that the patient ACTUALLY received to the planned dose of the standard regimen How do alkylating agents work? - Correct Answer By causing a break in the DNA helix strand, interfering with DNA replication and causing cell death

3 subcategories of alkylating agents: - Correct Answer 1. Nitrogen mustards

• Platinum-based agents (do not possess an alkyl group but still termed alkylating agents as they work

similarly)

• Nitrosoureas

Most common subcategory of alkylating agents: - Correct Answer Nitrogen mustards 2 / 3

Common alkylating agents: - Correct Answer Cyclophosphamide (Cytoxan)

Ifosfamide (Ifex) Bendamustine (Treanda)

Common platinum-based agents: - Correct Answer Cisplatin (Platinol)

Carboplatin (Paraplatin) What is unique about nitrosoureas agents? - Correct Answer Able to cross the blood-brain barrier; can be effective in treating some brain tumors

Common nitrosoureas agents: - Correct Answer Carmustine (BiCNU)

Lomustine (CeeNu) Streptozocin (Zanosar)

Hypersensitivity can occur with late doses of: - Correct Answer Carboplatin

These agents are typically categorized as highly emetogenic: - Correct Answer 1. Alkylating agents

• Nitrosoureas

Pre-administration labs for alkylating agents and nitrosoureas: - Correct Answer BUN Creatinine CBC w/ diff What is the medication Mesna used for? - Correct Answer Bladder protectant with administration of cyclophosphamide or ifosfamide Instruct pts receiving ________ to avoid exposure to cold air and consuming cold fluids for 3-4 days following treatment - Correct Answer Oxaliplatin

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