GENES, CHROMOSOMES, AND

EXAM ELABORATIONS Aug 27, 2025

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PART ONE

GENES, CHROMOSOMES, AND

HEREDITY

 

  • Introduction to Genetics 1
  • Mitosis and Meiosis 14
  • Mendelian Genetics 36
  • Extensions of Mendelian Genetics 62
  • Chromosome Mapping in Eukaryotes 94
  • Genetic Analysis and Mapping in Bacteria and

    • Bacteriophages

 123

  • Sex Determination and Sex Chromosomes 151

8 Chromosomal Mutations: Variation in Number

and Arrangement

 171

  • Extranuclear Inheritance 196

PART TWO

DNA: STRUCTURE, REPLICATION,

AND ORGANIZATION

  10 DNA Structure and Analysis 213 11 DNA Replication and Recombination 238 12 DNA Organization in Chromosomes 263

PART THREE

GENE EXPRESSION AND ITS

REGULATION

13 The Genetic Code and Transcription 283 14 Translation and Proteins 312 15 Gene Mutation, DNA Repair, and Transposition

 340

16 Regulation of Gene Expression in Bacteria 373 17 Transcriptional Regulation in Eukaryotes 393 18 Posttranscriptional Regulation in Eukaryotes

 413

19 Epigenetic Regulation of Gene Expression 433

PART FOUR

GENETIC TECHNOLOGY AND

GENOMICS

  20 Recombinant DNA Technology 454 21 Genomic Analysis 485 22 Applications of Genetic Engineering and Biotechnology

 521

PART FIVE

GENETIC ANALYSIS OF ORGANISMS

AND POPULATIONS

  23 Developmental Genetics 555 24 Cancer Genetics 579 25 Quantitative Genetics and Multifactorial Traits

 599

26 Population and Evolutionary Genetics 621 Brief Contents

SPECIAL TOPICS IN MODERN

GENETICS

  • CRISPR-Cas and Genome Editing 649
  • DNA Forensics 661
  • Genomics and Precision Medicine 672
  • Genetically Modified Foods 683
  • Gene Therapy 695

6 Advances in Neurogenetics: The Study of

Huntington Disease

 710

Appendix A  Selected Readings A-1 Appendix B  Answers to Selected Problems B-1 Glossary G-1 Credits C-1 Index I-1 Nobel Prizes Awarded for Research in Genetics or Genetics-Related Areas YearRecipientsNobel PrizeDiscovery/Research Topic 2017J. C. Hall

  • Rosbash
  • W. Young

    • Physiology or Medicine Identification of the genes and molecular mechanisms that regulate circadian rhythms 2015T. Lindahl

  • Modrich
  • Sancar

    • Chemistry Mechanistic studies of DNA repair 2012J. B. Gurdon

  • Yamanaka

    • Physiology or Medicine Differentiated cells can be reprogrammed to become pluripotent 2009V. Ramakrishnan

  • A. Steitz
  • E. Yonath

    • Chemistry Structure and function of the ribosome 2009E. H. Blackburn

  • W. Greider
  • W. Szostak

    • Physiology or Medicine The nature and replication of the DNA of telomeres, and the discovery of the telomere-replenishing ribonu- cleoprotein enzyme telomerase 2008O. Shimomura

  • Chalfie
  • Y. Tsien

    • Chemistry Discovery and development of a genetically encoded fluorescent protein as an in vivo marker of gene expression 2007M. R. Capecchi

  • J. Evans
  • Smithies

    • Physiology or Medicine Gene-targeting technology essential to the creation of knockout mice serving as animal models of human disease 2006R. D. Kornberg Chemistry Molecular basis of eukaryotic transcription 2006A. Z. Fire

  • C. Mello

    • Physiology or Medicine Gene silencing using RNA interference (RNAi) 2004A. Ciechanover

  • Hershko
  • Rose

    • Chemistry Regulation of protein degradation by the proteasome 2002S. Brenner

  • R. Horvitz
  • E. Sulston

    • Physiology or Medicine Genetic regulation of organ development and pro- grammed cell death (apoptosis) 2001L. H. Hartwell

  • Hunt
  • M. Nurse

    • Physiology or Medicine Genes and regulatory molecules controlling the cell cycle 1999G. Blobel Physiology or Medicine Genetically encoded amino acid sequences in proteins that guide their cellular transport 1997S. B. Prusiner Physiology or Medicine Prions—a new biological principle of infection 1995E. B. Lewis

  • NÜsslein-Volhard
  • Wieschaus

    • Physiology or Medicine Genetic control of early development in Drosophila 1993R. J. Roberts

  • A. Sharp

    • Physiology or Medicine RNA processing of split genes

  • B. Mullis
  • Smith

    • Chemistry Development of polymerase chain reaction (PCR) and site-directed mutagenesis (SDM) 1989J. M. Bishop

  • E. Varmus

    • Physiology or Medicine Role of retroviruses and oncogenes in cancer

  • R. Cech
  • Altman

    • Chemistry Ribozyme function during RNA splicing 1987S. Tonegawa Physiology or Medicine Genetic basis of antibody diversity CVR_KLUG4718_12_SE_BEP.indd 2-312/1/17 1:02 PM 2 / 4

PART ONE

GENES, CHROMOSOMES, AND

HEREDITY

 

  • Introduction to Genetics 1
  • Mitosis and Meiosis 14
  • Mendelian Genetics 36
  • Extensions of Mendelian Genetics 62
  • Chromosome Mapping in Eukaryotes 94
  • Genetic Analysis and Mapping in Bacteria and

    • Bacteriophages

 123

  • Sex Determination and Sex Chromosomes 151

8 Chromosomal Mutations: Variation in Number

and Arrangement

 171

  • Extranuclear Inheritance 196

PART TWO

DNA: STRUCTURE, REPLICATION,

AND ORGANIZATION

  10 DNA Structure and Analysis 213 11 DNA Replication and Recombination 238 12 DNA Organization in Chromosomes 263

PART THREE

GENE EXPRESSION AND ITS

REGULATION

13 The Genetic Code and Transcription 283 14 Translation and Proteins 312 15 Gene Mutation, DNA Repair, and Transposition

 340

16 Regulation of Gene Expression in Bacteria 373 17 Transcriptional Regulation in Eukaryotes 393 18 Posttranscriptional Regulation in Eukaryotes

 413

19 Epigenetic Regulation of Gene Expression 433

PART FOUR

GENETIC TECHNOLOGY AND

GENOMICS

  20 Recombinant DNA Technology 454 21 Genomic Analysis 485 22 Applications of Genetic Engineering and Biotechnology

 521

PART FIVE

GENETIC ANALYSIS OF ORGANISMS

AND POPULATIONS

  23 Developmental Genetics 555 24 Cancer Genetics 579 25 Quantitative Genetics and Multifactorial Traits

 599

26 Population and Evolutionary Genetics 621 Brief Contents

SPECIAL TOPICS IN MODERN

GENETICS

  • CRISPR-Cas and Genome Editing 649
  • DNA Forensics 661
  • Genomics and Precision Medicine 672
  • Genetically Modified Foods 683
  • Gene Therapy 695

6 Advances in Neurogenetics: The Study of

Huntington Disease

 710

Appendix A  Selected Readings A-1 Appendix B  Answers to Selected Problems B-1 Glossary G-1 Credits C-1 Index I-1 Nobel Prizes Awarded for Research in Genetics or Genetics-Related Areas YearRecipientsNobel PrizeDiscovery/Research Topic 2017J. C. Hall

  • Rosbash
  • W. Young

    • Physiology or Medicine Identification of the genes and molecular mechanisms that regulate circadian rhythms 2015T. Lindahl

  • Modrich
  • Sancar

    • Chemistry Mechanistic studies of DNA repair 2012J. B. Gurdon

  • Yamanaka

    • Physiology or Medicine Differentiated cells can be reprogrammed to become pluripotent 2009V. Ramakrishnan

  • A. Steitz
  • E. Yonath

    • Chemistry Structure and function of the ribosome 2009E. H. Blackburn

  • W. Greider
  • W. Szostak

    • Physiology or Medicine The nature and replication of the DNA of telomeres, and the discovery of the telomere-replenishing ribonu- cleoprotein enzyme telomerase 2008O. Shimomura

  • Chalfie
  • Y. Tsien

    • Chemistry Discovery and development of a genetically encoded fluorescent protein as an in vivo marker of gene expression 2007M. R. Capecchi

  • J. Evans
  • Smithies

    • Physiology or Medicine Gene-targeting technology essential to the creation of knockout mice serving as animal models of human disease 2006R. D. Kornberg Chemistry Molecular basis of eukaryotic transcription 2006A. Z. Fire

  • C. Mello

    • Physiology or Medicine Gene silencing using RNA interference (RNAi) 2004A. Ciechanover

  • Hershko
  • Rose

    • Chemistry Regulation of protein degradation by the proteasome 2002S. Brenner

  • R. Horvitz
  • E. Sulston

    • Physiology or Medicine Genetic regulation of organ development and pro- grammed cell death (apoptosis) 2001L. H. Hartwell

  • Hunt
  • M. Nurse

    • Physiology or Medicine Genes and regulatory molecules controlling the cell cycle 1999G. Blobel Physiology or Medicine Genetically encoded amino acid sequences in proteins that guide their cellular transport 1997S. B. Prusiner Physiology or Medicine Prions—a new biological principle of infection 1995E. B. Lewis

  • NÜsslein-Volhard
  • Wieschaus

    • Physiology or Medicine Genetic control of early development in Drosophila 1993R. J. Roberts

  • A. Sharp

    • Physiology or Medicine RNA processing of split genes

  • B. Mullis
  • Smith

    • Chemistry Development of polymerase chain reaction (PCR) and site-directed mutagenesis (SDM) 1989J. M. Bishop

  • E. Varmus

    • Physiology or Medicine Role of retroviruses and oncogenes in cancer

  • R. Cech
  • Altman

    • Chemistry Ribozyme function during RNA splicing 1987S. Tonegawa Physiology or Medicine Genetic basis of antibody diversity CVR_KLUG4718_12_SE_BEP.indd 2-312/1/17 1:02 PM 3 / 4

YearRecipientsNobel PrizeDiscovery/Research Topic 1985M. S. Brown

  • L. Goldstein

    • Physiology or Medicine Genetic regulation of cholesterol metabolism 1983B. McClintock Physiology or Medicine Mobile genetic elements in maize 1982A. KlugChemistry Crystalline structure analysis of significant complexes, including tRNA and nucleosomes 1980P. Berg

  • Gilbert
  • Sanger

    • Chemistry Development of recombinant DNA and DNA sequenc- ing technology 1978W. Arber

  • Nathans
  • O. Smith

    • Physiology or Medicine Recombinant DNA technology using restriction endo- nuclease technology 1976B. S. Blumberg

  • C. Gajdusek

    • Physiology or Medicine Elucidation of the human prion-based diseases, kuru and Creutzfeldt-Jakob disease 1975D. Baltimore

  • Dulbecco
  • M. Temin

    • Physiology or Medicine Molecular genetics of tumor viruses 1972G. M. Edelman

  • R. Porter

    • Physiology or Medicine Chemical structure of immunoglobulins

  • B. Anfinsen Chemistry Relationship between primary and tertiary structure

    • of proteins 1970N. Borlaug Peace Prize Genetic improvement of Mexican wheat 1969M. Delbrück

  • D. Hershey
  • E. Luria

    • Physiology or Medicine Replication mechanisms and genetic structure of bacteriophages 1968H. G. Khorana

  • W. Nirenberg
  • W. Holley

    • Physiology or Medicine For their interpretation of the genetic code and its function during protein synthesis 1966P. F. Rous Physiology or Medicine Viral induction of cancer in chickens 1965F. Jacob

  • M. Lwoff
  • L. Monod

    • Physiology or Medicine Genetic regulation of enzyme synthesis in bacteria 1962F. H. C. Crick

  • D. Watson
  • H. F. Wilkins

    • Physiology or Medicine Double helical model of DNA

  • C. Kendrew
  • F. Perutz

    • Chemistry Three-dimensional structure of globular proteins 1959A. Kornberg

  • Ochoa

    • Physiology or Medicine Biological synthesis of DNA and RNA 1958G. W. Beadle

  • L. Tatum

    • Physiology or Medicine Genetic control of biochemical processes

  • Lederberg Physiology or

    • Medicine Genetic recombination in bacteria

  • Sanger Chemistry Primary structure of proteins

    • 1954L. C. Pauling Chemistry Alpha helical structure of proteins 1946H. J. MÜllerPhysiology or Medicine X-ray induction of mutations in Drosophila 1933T. H. Morgan Physiology or Medicine Chromosomal theory of inheritance 1930K. Landsteiner Physiology or Medicine Discovery of human blood groups CVR_KLUG4718_12_SE_BEP.indd 4-512/1/17 1:02 PM

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Category: EXAM ELABORATIONS
Added: Aug 27, 2025
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Untitled-16 9:25 PM PART ONE GENES, CHROMOSOMES, AND HEREDITY   1 Introduction to Genetics 1 2 Mitosis and Meiosis 14 3 Mendelian Genetics 36 4 Extensions of Mendelian Genetics 62 5 Chrom...

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