High Yield Drug List 2025 updated Penicillin - ANSWER Abx
MOA: Bind PBP (transpeptidases), block transpeptidase cross-linking
peptidoglycan, activate autolytic enzymes. (D-alanine D-Alanine)
Use: GP orgs (S. pneumo, S. pyogenes, Actinomyces). Also N. meningitidis, and
Treponema pallidum. Bactericidal for GPC, GPR, GNC and spirochetes.
Resistance: B-lactamases cleave B-lactam ring
Tox: Hypersensitivity rxns
hemolytic anemia Conivaptan, Tolvaptan, demeclocycline - ANSWER ADH antagonist for SIADH syndrome, demo is part of of tetra cycles.
Glucagon - ANSWER MOA: Gs increases cAMP
Use: B-blocker overdose
Iodine 123 - ANSWER Radioactice Tx for hyperthyroidism. Can be offset by potassium Iodine to protect in case of overdose exposure by competitive inhibition of the Na symptom on the basolateral surface. 1 / 4
Potassium Perchlorate - ANSWER Use: Competitive inhibition of the iodine transort in the thyroid. Often used when radioactive iodine is used in hyperthyroidism. Na/perchlorate symporter. Radioactive iodine uptake will be reduced as pre-treatment per-surgery.
MOA:
Mebendazole, Albendazole - ANSWER Worms Pinworm - Helmith - Enerobius vermicuaris Whipworm Hookworm Roundworm Primaquine - ANSWER Anti malarial. Prevents relapse by killing dormant vivax and oval.Clavulanic Acid, Sulbactam, Tazobactam - ANSWER B- Lactamase inhibitor. Used with Pcn that are beta lactase . Pippercillin.Dimercaprol - ANSWER Arsenic OD. People with garlic breath.Displaces sulfhydryl groups from enzymes and helps excrete.Loperamide, Diphenyloxalate - ANSWER Anti-diarrhea. Opiod agonist. Reduces gut motility. Inhibits Ach release. Atropine is added to reduce abuse potential.Varenicline - ANSWER Nicotinic agonist. Smoking cessation.Decrease withdrawal. 2 / 4
Cromolyn, Nedocromil - ANSWER Mast cell stabilizer Prevent release of mast cell inflammatory mediators.Potassium Citrate - ANSWER USE: Prevention of calcium renal stones (Calcium Oxalate or Calcium Phosphate) with increased water intake.Propranolol - ANSWER Non-selective B1 / B2 receptor antagonist.Will lower heart rate AND reduce renin form JG cells in renal.
Cladribine (2CDA) - ANSWER Use: Hairy Cell Leukemia
MOA: Purine analog that blocks Adenosine Deaminase
if CD20, you can throw in Rituximab as well.
AE: Fever, sulfa drug Rxn,
Riluzol - ANSWER ALS drug (only one) Riluzole preferentially blocks TTX-sensitive sodium channels, which are associated with damaged neurons.Penicillamine - ANSWER Copper chelator used in Wilsons Disease. (until liver transplant) 3 / 4
Alprostidile - ANSWER PGE2 analog used for PDA to keep it open in cases where another heart disorder benefits from the open connection...such as Turners Syndrome.Transposition of Great Vessels, Pre-ductal coarctation, metrology of Fallot, and other R to L shunts such as Tricuspid Atresia...where they die without it.
MOA: Vasodilates. Also can give an erection because it vasodilates. Given by
injection but not used for this purpose.Hydroxy Cobalamin - ANSWER First line cyanide drug. A B-12 derivative that creates Cyanocobalamin. It doesn't create the anemia that using Nitrites would (with brown blood Fe / CN)...and followed up by Thiosulfate. The conversion of hemoglobin to myoglobin causes the anemia with the old drugs.Ivacaftor - ANSWER The only CFTR drug for the 5% genetic gate blockage disorder at position G551D, glycine replace with aspartic acid. Gate damaged. The only CF drug created.Penicillamine, Trimemptine - ANSWER Copper chelation in Wilsons Disease (AR). If the Pt has hepatic encephalopathy, you can also use Lactulose.IV Anesthetics - ANSWER Barbituates - thiopental (rapid, short surgery) Benzos - Midazolam (endoscopy) Ketamine (Arylcyclohexlamines) - PCP analog Opiods - Morphine. Fentanyl - combo w a general Propofol - less vomits but high CV depression
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