KUBY IMMUNOLOGY 7TH EDITION BY OWEN TEST BANK

KUBY IMMUNOLOGY 7TH EDITION BY OWEN TEST BANK

Table of Contents Part I Introduction

• Overview of the Immune System
• Cells, Organs, and Microenvironments of the Immune System

3. Receptors and Signaling: B and T Receptors

4. Receptors and Signaling: Cytokine and Chemokine

Part II Innate Immunity

• Innate Immunity
• The Complement System

Part III Adaptive Immunity: Antigen receptors and MHC

• Organization and Expression of Lymphocyte Receptor Genes
• The Major Histocompatibility Complex and Antigen Presentation

Part IV Adaptive Immunity: Development

• T-Cell Development
• B-Cell Development

Part V Adaptive Immunity: Effector Responses

• T-cell Activation, Differentiation, and Memory
• B-cell Activation, Differentiation, and Memory

13. Effector Responses: Cell and Antibody -Mediated Immunity

• Immune Responses in Time and Space

Part VI The Immune System in Health and Disease

15. Inflammation: Allergy and Hypersensitivities

• Tolerance, Autoimmunity, and Transplantation
• Infectious Diseases and Vaccines
• Immunodeficiency Disorders
• Cancer and the Immune System

Part VII Experimental Methods

• Experimental Methods
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• Which of the following is the BEST example of herd immunity?

Chapter 1 Overview if the Immune System

• Which is the best definition of □immunity□?
• The state of having been exposed to a pathogen repeatedly
• The state of being resistant to reinfection with a pathogen
• When an individual has never been exposed to a pathogen
• When the immune system is activated
• When physical barriers are not enough to prevent infection

Answer: B

Section: A Historical Perspective

Difficulty: 1

Hint: Vaccines can induce immunity.

• What happens to a pathogen as it becomes attenuated?
• It becomes more dangerous to the host.
• It gets smaller.
• It has weakened virulence.
• At becomes older.
• All of the above

Answer: C

Section: A Historical Perspective

Difficulty: 2

Hint: Attenuated viruses are used as vaccines.

• A child infected with measles travels from Germany to the United States.

Several babies contract the disease, but the outbreak is largely contained due to vaccinations.

• Certain populations of cattle are less susceptible to infection with enc

ephalitis because of their genetic makeup.

• Once a certain threshold of individuals has been infected with a novel h

uman pathogen, it is unlikely that any more will be.

• Geese and chickens are infected with different strains of influenza beca

use they express different receptors on their cell surface.

• When infection spreads through a population, certain individuals generat

e stronger immune responses than others.

Answer: A

Section: A Historical Perspective

Difficulty: 2

Hint: The herd protects the individual.

• Which of the following diseases does NOT currently have an effective vac

cine?

• Chicken pox
• Polio

C. HIV

• Small pox
• Diptheria

Answer: C

Section: A Historical Perspective

Difficulty: 1

Hint: Most vaccines protect almost everyone from infection. 2 / 4

• Two main early theories were proposed to explain how antigen-specific an

two differ? Which was ultimately shown to be CORRECT?

• Which of the following is a fungal pathogen?

5. Effectors of the humoral immune system are known as:

• antibodies.
• immunoglobulin.
• complement.
• B cells.
• All of the above

Answer: E

Section: A Historical Perspective

Difficulty: 1

Hint: There is a cellular and a humoral component to the adaptive immune respons e.

• Which of the following cell types are lymphocytes?
• Macrophages
• Mast cells
• Neutrophils
• Erythrocytes
• T cells

Answer: E

Section: A Historical Perspective

Difficulty: 1

Hint: lymphocytes are involved in adaptive immunity.

• Which of the following is TRUE about antigens?
• They are always derived from pathogens.
• They are always proteins.
• They are recognized by T cells or B cells.
• They must be microbial in origin.
• They usually cause cellular damage.

Answer: C

Section: A Historical Perspective

Difficulty: 1

Hint: There are many kinds of antigens.

Answer: The selective theory says that, when an antigen receptor binds with an a ntigen, the cell becomes activated (or the cell is selected to proliferate and s ecrete more copies of the receptor). The instructional theory says that the anti gen receptor molds itself to the antigen. The selective theory was shown to be c orrect.

Section: A Historical Perspective

Difficulty: 3

Hint: There is a cellular and a humoral component to the adaptive immune respons e.

• Vibrio cholerae
• Leishmania major
• Poliovirus

tibodies develop: the instructional theory and the selective theory. How did the 3 / 4

• Candida albicans
• Bordetella pertussis

Answer: D

Section: Important Concepts for Understanding the Mammalian Immune Response

Difficulty: 1

Hint: Yeasts are fungi.

• Which of the following cell types is MOST commonly associated with recog

nizing antigens found inside of cells?

• Macrophages
• B cells
• Th cells

D. CTL

• Antibodies

Answer: D

Section: Important Concepts for Understanding the Mammalian Immune Response

Difficulty: 1

Hint: Viruses are found inside of cells.

• Which of the following classes of cell surface receptors are directly en

coded in the germline?

A. TCR

B. BCR

C. PRR

• Antibodies
• All of the above

Answer: C

Difficulty: 1

Section: Important Concepts for Understanding the Mammalian Immune Response

Hint: Some receptors are randomly generated rather than encoded in the germline.

• What is the central mechanism for establishing self-tolerance?
• Self-reactive T cells and B cells are killed during development.
• Individuals that have immune systems that respond to self-antigens do no

t survive to reproduce.

• Immune cells that react to self-antigens are turned off when they recogn

ize self-tissues.

• Certain immune suppressive cytokines are maintained in tissues to dampen

auto reactive immune responses.

• Peripheral tissues have mechanisms to kill T or B cells that respond to

them.

Answer: A

Section: Important Concepts for Understanding the Mammalian Immune Response

Difficulty: 1

Hint: Central tolerance develops as cells are maturing.

• Complete the following table comparing and contrasting innate and adapti

ve immune responses.Innate Immunity Adaptive Immunity Is mediated by what cells?What do they recognize?How are the receptors encoded?

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