Meyer Test Bank - Meyer Test Bank Chapter 1: Principles of Pharma...

Psychopharmacology Drugs the Brain and Behavior 3rd Edition Meyer Test Bank

Chapter 1: Principles of Pharmacology

Multiple Choice

• refer(s) to specific molecular changes that occur when a drug binds to a

particular target site or receptor, while are the resulting widespread alterations in function.

• Drug action; therapeutic effects
• Side effects; drug effects
• Therapeutic effects; side effects
• Drug action; drug effects

Answer: d

Textbook Reference: Pharmacology: The Science of Drug Action

• After drug administration has occurred, the amount of drug in the blood that is free to

bind at specific target sites is referred to as

• the therapeutic dose.
• first-pass effects.
• bioavailability.
• ED50.

Answer: c

Textbook Reference: Pharmacokinetic Factors Determining Drug Action

• The specific molecular changes that occur when a drug binds to a particular target site

or receptor are referred to as

• drug effects.
• drug action.
• side effects.
• placebo effects.

Answer: b

Textbook Reference: Pharmacology: The Science of Drug Action

• Which of the following is not a possible explanation for placebo effects?
• Pavlovian conditioning
• Genetic variation
• Drug competition
• Expectation of outcome

Answer: c

Textbook Reference: Pharmacology: The Science of Drug Action 1 / 4

• The administration of oxytocin has been proposed as a treatment for autism.
• intravenous
• oral
• intranasal
• intracerebral

Answer: c

Textbook Reference: Pharmacokinetic Factors Determining Drug Action

• Which factor does not affect the pharmacokinetics of a drug?
• Route of administration
• Lipid solubility
• Depot binding
• Drug action

Answer: d

Textbook Reference: Pharmacokinetic Factors Determining Drug Action

• First-pass metabolism occurs when drugs are taken
• orally.
• intravenously.
• subcutaneously.
• nasally.

Answer: a

Textbook Reference: Pharmacokinetic Factors Determining Drug Action

• The area postrema is one area in the brain where the is not complete.
• cerebrospinal fluid
• blood–brain barrier
• choroid plexus
• phospholipid membrane

Answer: b

Textbook Reference: Pharmacokinetic Factors Determining Drug Action

• First-pass metabolism occurs with orally administered drugs because
• their absorption is slowed by food.
• drugs absorbed into the bloodstream from the stomach go to the liver on the way to

general circulation.

• drugs must first survive the acidic environment of the stomach.
• salivary enzymes in the mouth begin the process of metabolism.

Answer: b

Textbook Reference: Pharmacokinetic Factors Determining Drug Action

• Toxic substances in the blood trigger a vomiting response by activating the
• blood–brain barrier.
• choroid plexus.
• area postrema.
• median eminence. 2 / 4

Answer: c

Textbook Reference: Pharmacokinetic Factors Determining Drug Action

• Drugs administered _ have the most rapid onset of action.
• subcutaneously
• intramuscularly
• orally
• intravenously

Answer: d

Textbook Reference: Pharmacokinetic Factors Determining Drug Action

• Ionization of a drug depends on the of the solution and the of the

drug.

• pH; pKa
• pKa; pH
• concentration; lipid solubility
• pH; concentration

Answer: a

Textbook Reference: Pharmacokinetic Factors Determining Drug Action

• The absorption of a drug depends on all of the following except
• lipid solubility.
• ionization.
• body temperature.
• the concentration of the drug.

Answer: c

Textbook Reference: Pharmacokinetic Factors Determining Drug Action

• Drugs that are should be avoided by women of childbearing age.
• teratogenic
• able to cross the placental barrier
• psychoactive
• highly lipid-soluble

Answer: a

Textbook Reference: Pharmacokinetic Factors Determining Drug Action

• Agents that induce developmental abnormalities in a fetus are known as
• psychoactive drugs.
• illicit drugs.
• teratogens.
• placental drugs.

Answer: c

Textbook Reference: Pharmacokinetic Factors Determining Drug Action

• Depot binding is said to occur when drugs
• bind to their target sites. 3 / 4

• bind to inactive sites.
• compete for binding sites.
• are excreted before binding.

Answer: b

Textbook Reference: Pharmacokinetic Factors Determining Drug Action

• Which statement about depot binding is false?
• It reduces the concentration of drug at its site of action.
• It may delay the onset of drug action.
• It may prolong drug action by disrupting normal metabolism.
• It increases the concentration of drug at its site of action by releasing large quantities at

once.

Answer: d

Textbook Reference: Pharmacokinetic Factors Determining Drug Action

• Drug metabolism mostly occurs in the and usually makes a drug more

soluble.

• kidneys; fat
• liver; fat
• liver; water
• kidneys; water

Answer: c

Textbook Reference: Pharmacokinetic Factors Determining Drug Action

• Which statement about drug clearance by first-order kinetics is false?
• Molecules of a drug are cleared at a constant rate regardless of drug concentration.
• Molecules of a drug are cleared at an exponential rate.
• A constant fraction of the free drug in the blood is removed in each time interval.
• Clearance of most drugs occurs in this manner.

Answer: a

Textbook Reference: Pharmacokinetic Factors Determining Drug Action

• Ethyl alcohol (ethanol) is an example of a drug that is eliminated
• by first-order kinetics.
• by zero-order kinetics.
• by second-order kinetics.
• at the point that six half-lives have passed.

Answer: b

Textbook Reference: Pharmacokinetic Factors Determining Drug Action

• Biotransformation of drugs in the liver often occurs in two stages; phase I changes are

and include .

• nonsynthetic; conjugation
• synthetic; conjugation
• nonsynthetic; oxidation
• synthetic; oxidation
• / 4