Molecular Diagnostics 3rd Edition Buckingham

Molecular Diagnostics 3rd Edition Buckingham Test Bank

Chapter 1: Nucleic Acids and Proteins

Multiple Choice

• DNA contains deoxyribonucleotide triphosphates joined together by what type of covalent

bond?

• Aldehyde
• Ester
• Phosphodiester
• Peptide

ANS: C

OBJ: 1-2

• Nucleotides in DNA consist of which of the following?
• Nitrogen base, deoxyribose, and phosphate
• Nitrogen base, ribose, and sulfur
• Carbon base, ribose, and phosphate
• Carbon base, glucose, and carbToExSyl

ANS: A

OBJ: 1-1

• Which of the five ribose carbons of the deoxyribonucleotide are involved in the formation of

the DNA chain?

• 1' and 5'
• 2' and 4'
• 3' and 4'
• 3' and 5' 1 / 4

ANS. D

OBJ: 1-23

• In a DNA molecule, one end has a free hydroxyl group, and one end has a free
• phosphate group.
• hydroxyl group.
• amino group.
• carboxyl group.

ANS: A

OBJ: 1-1

• What type of bonds spontaneously form between two complementary strands of DNA?
• Hydrogen bonds
• Covalent bonds
• Phosphodiester bonds
• Polar covalent bonds

ANS: C

OBJ: 1-2

• In a double-stranded DNA molecule, base pairing between strands occurs between
• a purine and a purine.
• a pyrimidine and a pyrimidine.
• a purine and a pyrimidine.
• all types of nucleotide bases.

ANS: C

OBJ: 1-1

• Which of the following is a purine?
• Thymine
• Cytosine
• Adenine
• Alanine

ANS: C 2 / 4

OBJ: 1-1

• Which DNA sequence is complementary to 5'GATTCTCAAAGGACT3'?

A. 5'GATTCTCAAAGGACT3'

B. 3'GATTCTCAAAGGACT5'

C. 3'CTAAGAGTTTCCTGA5'

D. 5'CTAAGAGTTTCCTGA3'

ANS: C

OBJ: 1-7

• The term used to describe the arrangement of the individual strands in the double-stranded

DNA molecule is

• parallel.
• antiparallel.
• tangential.
• divergent.

ANS: B

OBJ: 1-7

• The process of separating the two DNA strands into two single strands is called
• denaturation.
• bidirectional.
• depolymerization.
• synthesis.

ANS: A

OBJ: 1-2 3 / 4

• DNA replication is
• conservative.
• semiconservative.
• nonconservative.
• dispersive.

ANS: B

OBJ: 1-3

• DNA replication requires the presence of
• DNA template.
• ribosomes.
• amino acids.
• messenger RNA.

ANS: A

OBJ: 1-3

• DNA replication of the leading strand proceeds with the new daughter strand synthesized in

which orientation?

• 5' to 3'
• 3' to 5'.
• Discontinuously.
• Either 5' to 3' or 3' to 5'

ANS: A

OBJ. 1-7

• In DNA replication, the leading strand is copied in which direction?
• Reading goes 5 to 3
• Reading goes 3 to 5
• Both strands are leading.
• Reading proceeds from the -OP to the -OH end.

ANS: B

OBJ: 1-7

• / 4