MRCP Part 1 EXAM QUESTIONS AND ANSWERS 100% SOLVED (Newest 2025) Pregnancy and Thyroid Hormone - Correct Answers ✅Pregnancy increases the amount of TBG (thyroid binding globulin) so increases the total thyroxin levels but not free thyroxine Hyperthyroid in pregnancy - Correct Answers ✅Untreated - fetal loss, premature labour, maternal heart failure Graves disease most common HCG can activate TSH receptors - transient gestational hyperthyroid - these fall in trimester 2 & 3 treatment - propylthiouracil in first trimester this can cause hepatic injury carbimazole in 2nd trimester once lower risk of congenital abnormalities Monitoring - free thyroxine levels should be kept upper third normal so to avoid fetal hypothyroid
- thyrotrophin receptor stimulating antibodies should be
checked weeks 30-36 DO NOT - block and replace or use radioiodine.Hypothyroid in pregnancy - Correct Answers ✅Thyroxine replacement is safe in pregnancy and breastfeeding TSH measured each trimester and 6-8 weeks post partum Women often require an increased dose - up to 50% by weeks 4-6 untreated - developmental abnormalities, miscarriage, still birth, low birth weight, pre-eclampsia, anaemia 1 / 4
MRCP Part 1 EXAM QUESTIONS AND ANSWERS 100% SOLVED (Newest 2025) Gentamicin - Correct Answers ✅Aminoglycoside antibioitic Given IV or topically Ototoxic - irreversible due to auditory or vestibular nerve damage Nephrotoxic - causes tubular necrosis, accumulates in renal failure requiring increased monitoring, furosemide increases this risk CI - Myasthenia Gravis Dosed via height and weight and renal function. Peak and trough levels monitored with dose adjustments based on trough levels
CSF: Protein levels - Correct Answers ✅normal = 0.2-0.4
g/L Causes of raised CSF protein GBS Froin's syndrome - a spinal canal blockage characterised by xanthochromia, raised protein and CSF hypercoagulability TB, bacterial or fungal meningitis viral encephalitis Vigabatrin - Correct Answers ✅Irreversibly inhibits GABA transaminase-->increased GABA levels in synapse 2 / 4
MRCP Part 1 EXAM QUESTIONS AND ANSWERS 100% SOLVED (Newest 2025) Uses = tx infantile spasms (Viga"Baby"trin) Or used as adjunct therapy for adults with refractory complex partial seizures SE = visual field constriction and even visual loss in 40% of patients- visual fields must be checked every 6 months as visual loss can be irreversible
Tricuspid regurgitation - Correct Answers ✅Signs:
pansystolic murmer, parasternal heave, giant V waves, pulsatile hepatomegaly
causes: IVDU endocarditis, rheumatic heart disease, right
ventricle infarction, pulmonary hypertension, carcinoid syndrome, epsteins anamoly (rare heart defect that causes tricuspid regurg) Corticosteroid side effects - Correct Answers ✅COME IN PIGG Cushings opthalmic - glaucoma, catterachts M - musculoskeletal - OP, proximal myopathy, avascular necrosis Endocrine- hyperglycaemia, weight gain, hirsuitism, high lipids Immunosupression 3 / 4
MRCP Part 1 EXAM QUESTIONS AND ANSWERS 100% SOLVED (Newest 2025) Neutrophilia Psychiatric - mania, psychosis, insomnia, depression Intracranial hypertension Gastric - pancreatitis, ulcers, Growth suppression in kids Acne - Systemic glucocorticoids can cause drug-induced acne. This is characterised as monomorphic papular rash without comedones or cysts. This does not respond to acne treatment but improves on drug discontinuation Therapeutic Steroids - Correct Answers ✅Fludocortisone - mostly mineralocorticoid hydrocortisone - some glucocorticoid, some mineralocoticoid Dexamethsone - high glucocorticoid Medication overuse headache - Correct Answers ✅Headache for over 15 days a month, whilst taking regular analgesia triptans and opioids are highest risk very common, can affect 1/50 people management - stop simple analgesia and triptans, wean down any opioids
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