MSN 571 Pharm Midterm; Final Exam

MSN 571 Pharm Midterm; Final Exam

• Fluoroquinolone antibiotics are most likely indicating in which of the

conditions Asthma Genital infections Follicular conjunctivitis GERD

• Which of the following is most likely an intervention for otitis media?

Amoxicillin Aspirin Immunoglobulins Corticosteroids

• Which of the following best classifies penicillin, cephalosporins, and

Protein synthesis inhibitors Mycolic acid synthesis inhibitors RNA synthesis Cell wall inhibitors

• Beta lactamase inhibitors are often located in which of the following?

May decrease absorption First dose effect Often combined with penicillin antibiotics Delayed absorption of oral drugs

• Which of the following drug classes is/are used in initial hypertension

management of African American population? Clonidine primary Beta blockers primary Thiazide or calcium channel blocker primary 1 / 4

ACE-I primary ARB primary

• Which of the following groups of antibiotics is notable for side effects such as

nephrotoxicity or ototoxicity?Beta-lactams Aminoglycosides Tetracyclines

• Which of the following groups of antibiotics has a beta-lactam ring in the

molecular Structure Sulfonamides Macrolides Tetracyclines Fluoroquinolone Cephalosporins

• Which of the follow medication is a fluoroquinolone antibiotic?

Ciprofloxacin Azithromycin Amikacin Penicillin

• Which of the following medications or drugs classes is commonly indicated for

managing gestational hypertension?Spironolactone (Aldactone) Loop diuretics Calcium channel blockers Dobutamine Calcium gluconate 2 / 4

• Which of the following best classifies aminoglycosides, macrolides and

clindamycin?Protein synthesis inhibitor Folic acid synthesis inhibitors Cell wall inhibitors Mycolic acid synthesis inhibitors

• The long half-life of amiodarone contributes to which complications

Enhanced therapeutic effects Liver toxicity Decreased dosing Short onset of action

• Pharmacokinetics involves the study of which factor?

Distribution rates among various body compartment Physiologic interactions of drugs Interactions among various drugs Adverse reactions to medications

• Which route of drug administration is used with potent and lipophilic drugs in

a patch formulation and avoids first-pass metabolism?Oral Topical Rectal Transdermal

14. Patients who have a poor metabolism phenotype will have :

A need for increased dosages of medications Increased elimination of an active drug Accumulation of inactive metabolites of drugs 3 / 4

Slowed metabolism of prodrug into an active drug leading to accumulation of prodrug

• Lower doses of sublingual nitroglycerin can be used effectively because

It bypasses the liver The potency is 100 times higher It does not need to be absorbed into the bloodstream It is not catabolized down by gastric acids

• Which term refers to the ratio between a drugs therapeutic effects and its

toxic effects?Cumulative effect Therapeutic index Tolerance Affinity

• In geriatric patients the percentage of body fat is increased. What are the

pharmacologic implications of the physiologic change?A lipid soluble medication will be eliminated more quickly and not work as well Absorption of lipid soluble drugs is impaired in older adults.The bioavailability of the lipid soluble drug will be increased in older adults A lipid soluble medication will accumulate in fat tissue and its duration of action may be prolonged

• A patient diagnosed with otitis externa and taking a fluoroquinolone with

glucocorticoid benefit is taking the medication together you reply The glucocorticoid reduces the swelling caused by the inflammation and ear infection The glucocorticoid decreased likelihood of antibiotic resistant The glucocorticoid decreases the adverse effects of the fluoroquinolone The two medications are contraindicated for use together

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