NR566 F inal Exam Advanced Pharmacology

NR566 F inal Exam (Advanced Pharmacology for Care of the Family) Anti-Androgens (Answer)- Finasteride (Propecia) Leuprolide (Eligard, Lupron, Lupron Depot) Spironolactone (Aldactone) Finasteride (Propecia, Proscar) (Answer)- blocks conversion of testosterone to dihydrotesterone

Used to tx:

-BPH -male pattern baldness

• months of therapy need to see benefits

Stopping, reverses effect w/in 12 months

Adverse side effects:

• Decreased libido

-Impotence dutasteride (Avodart) (Answer)- 5-alpha reductase inhibitor

used to tx:

BPH Can stay in serum up to 6 mon after discontinuing can be absorbed through skin pregnant woman shouldn't handle capsules (fetal anomaly in male fetus) Adverse Effects decreased libido Impotence Leuprolide Acetate (Lupron) (Answer)- Luteinizing hormone - releasing agonist

create reversible:

-orchiectomy state -oophorectomy state

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Used to tx:

• advanced prostatic cancer
• Management of endometriosis
• Uterine fibroids
• polycystic ovarian disease
• central precocious puberty in peds

Flutamide (Eulexin, Euflex) (Answer)- Truly non-steroidal agent

Used to tx:

-Advanced prostate cancer -female androgen excess syndrome Adverse Effects in males

• gynecomastia

-reversible liver toxicity Black Box Warning -hepatic failure -hepatic encephalopathy Basline/monthly liver function test for 1st 4 months Spironolactone (Aldactone) (Answer)- aldosterone antagonist potassium sparing diuretic

used for tx:

-female hirsutism (abnormal growth of hair) -acne -relief of PMS/PMDD symptoms (25-50 mg/d) Adverse reactions

• dose related + reversible when discont.

-GI upset -Drowsiness -Gynecomastia -Impotence -Cutaneous (skin) eruptions

• Urticaria

Black Box Warning Tumorigenicity in animals

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