NSG 430 Exam 4 Sickle Cell Disease and Crisis
What is sickle cell disease?It is an inherited blood disorder that causes the change in the primary structure of the hemoglobin, and it makes the cells look like sickles.What organs are primarily affected in SCD?Lungs Kidneys Brain retina Bones What does the sickle cell shape cause?vascular occlusion leading to hemolysis What is Sickle Cell Crisis?A severe, painful, acute exacerbation of RBC sickling causing a vaso-occlusive crisis What does SCC lead to?tissue Ischemia, infarction, Necrosis --> Shock Who does SCD affect the most?Africans Sub Saharan Mediterranean Hispanics Main trigger for SCC?Low O2 tension in the blood
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