NSG 530 - Advanced Pathophysiology

NSG 530 - Advanced Pathophysiology

Exam 1

Question:

Which of the following is a flaw in the monoamine hypothesis of depression?

• Concentrations of neurotransmitters are reduced in the synaptic cleft
• A switch to a different class of antidepressants does not improve response
• Antidepressant response is associated with a therapeutic level of the

medication

• Antidepressant effects on neurotransmitters do not temporally

correspond to response.

Answer:

D

Question:

A 26-year-old patient with a first episode of depression has been treated with duloxetine 60 mg twice daily for the past 4 months. The patient would like to discontinue treatment. The patient should be told that they need at least _____full months of antidepressant therapy after reaching full remission.

• 3
• 6

C. 9 1 / 3

• 12

Answer:

B

Question:

Which of the side effects of trazodone for the treatment of depression is most frequently observed?

• Hematuria
• Delayed orgasm
• Priapism
• Orthostasis

Answer:

D

Question:

An antidepressant that may be dangerous in overdose is

• Mirtazapine
• Amitriptyline
• Fluoxetine
• Escitalopram

Answer:

B

• / 3

Question:

A 28-year-old man with a history of depression has been taking sertraline 200 mg daily for 12 weeks with no response. The patient has no other complaints. The physician asks for your recommendation. The most

reasonable recommendation would be to:

• Increase sertraline
• Add fluoxetine
• Switch to amitriptyline
• Change to venlafaxine

Answer:

D

Question:

AS is an 18-year-old woman hospitalized for the fourth time for major depressive disorder. On this occasion, AS was admitted for suicidal ideation.Her other symptoms include loss of appetite, insomnia, decreased energy, increased agitation, and anhedonia for the past 2 months. Although she did well her first semester of college, AS "partied: a lot and broke up with a new boyfriend. Two months ago, AS refused to go back to college after the winter holidays. She does not have any other medical problems. AS's mother and grandfather have a history of bipolar illness, and her father has a history of substance abuse. AS's symptoms meet the criteria for major depressive

disorder based upon the fact that she has:

• A history of mania
• A history of substance abuse
• Felt suicidal and had four target symptoms for more than 10 days
• Had a loss of pleasure and four target symptoms for more than 2 weeks.
• / 3