NSG6005 Advanced Pharmacology Quiz 1 Latest Update 2025-2026 Exam 110 Questions with 100% Verified Correct Answers Guaranteed A+
(CLAS) - CORRECT ANSWER: Culturally and Linguistically Appropriate Services
9 Barriers to Adherence of meds - CORRECT ANSWER: Perceived adverse drug
reactions Asymptomatic conditions Chronic conditions Knowledge deficit Cognitive impairment and psychiatric illness Complexity of drug regimen Financial impact of meds Communication difficulties Multiple providers
Alcohol - CORRECT ANSWER: Inhibits fat absorption and thereby inhibiting absorption of fat soluble vitamins
Calcium - CORRECT ANSWER: Deficiency related to fat malabsorption
Charged medications - CORRECT ANSWER: Water soluble and more easily eliminated
by the kidneys
Clinical implications when substrates induce CYP450 enzymes - CORRECT ANSWER:
How CYP inducers affect drug action An inducer may increase the metabolism of substrates and generally lead to a decreased drug effect.
Clinical implications when substrates inhibit CYP450 enzymes - CORRECT ANSWER:
How CYP inhibitors affect drug action An inhibitor may decrease the metabolism of substrates and generally lead to an increased drug effect.
Cruciferous antioxidant vegetables - CORRECT ANSWER: May increase the activity of drug-metabolizing enzymes
CYP:3A4 - CORRECT ANSWER: Metabolize 50% of all drugs
CYP1A2 - CORRECT ANSWER: Cruciferous vegetables, methylxanthine-containing
beverages (caffeine) and charcoal broiling by lead to therapeutic failure.
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Cytochrome P450 - CORRECT ANSWER: Enzymes located in liver or gut involved in
these reactions
Deamination - CORRECT ANSWER: Bodily process in which amino groups are
removed from excess proteins. This happens most often in the liver, though it also occurs in the kidneys.
Defects in CYP2C19 that cause slow acetylation - CORRECT ANSWER: Interfere with
mephenytoin metabolism Most common in Japanese
Defects in CYP2C9 that cause slow acetylation - CORRECT ANSWER: Multiple
variations of polymorphism Encode for decreased warfarin metabolism
Defects in CYP3A5 that cause slow acetylation - CORRECT ANSWER: Polymorphic
differences of 0% to 100% Caucasian 5% Japanese 29% Chinese 27% Koreans 30% African-Americans 73%
Disease states that effect metabolism - CORRECT ANSWER: Liver disease
Biliary disease Cardiac disease Respiratory disease Thyroid disease
Disease states that effect metabolism - CORRECT ANSWER: Release of inflammatory
mediators, nitrous oxide, cytokines associated with infection.Can inactivate or degrade CYP450 enzyme and reduce metabolism
Distribution - CORRECT ANSWER: Requires adequate blood supply. Drug goes to
areas of high blood flow first. Areas of low blood supply have a slower delivery
Ethnicities prone to slow acetylation - CORRECT ANSWER: Blacks 50%
Whites 50% Asians
Factors of rational drug selection - CORRECT ANSWER: Define the patient's problem Specify therapeutic objective Collaborate with patient Choose the treatment Educate patient Monitor effectiveness
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