NUR 108 Medications - Answer - Lipitor - Antihyperlipidemic (statin) ...

NUR 108 Medications

• Atorvastatin Calcium

Answer

• Lipitor
• Antihyperlipidemic (statin)
• Hyperlipidemia
• 10 to 80 mg qd
• Oral route any time of the day w or w/o food
• Contraindications

acute liver disease; hypersensitivity; breastfeeding; pregnancy

• Major interactions

atorvastatin; grapefruit juice

• Side effects;systemic vasculitis; alopecia; new onset diabetes mellitus; GI upset; acute

hepatitis; liver failure

• MOA; selectively and competitively inhibits HMG-CoA reductase, a rate-limiting enzyme

that converts 3-hydroxy-3-methylglutaryl-coenzyme A to mevalonate, a sterol and cholesterol precursor

• Levothyroxine

Answer

• Synthroid

• Diagnostic agent
• Hypothyroidism
• mcg increments
• Injection, IV, or oral
• Contraindications; AMI; hypersensitivity to glycerol; unable to swallow capsules; risk of

thyrotoxicosis; adrenal insufficiency

• Major interactions; drugs that increase BP; soy in diet may decrease effectiveness of drug 1 / 3

• Side effects; palpitations; alopecia; excessive sweating; weight loss; diarrhea; insomnia;

anxiety, fatigue; heart failure, MI; cardiac arrest; dyspnea; decreased bone density

• MOA; activates gene transcription and synthesis of messenger RNA and cytoplasmic proteins

• Lisinopril

Answer

• Prinivil, Zestril

• ACE Inhibitor; Antihypertensive
• Hypertension; AMI; heart failure
• mg
• oral route

• Contraindications

angioedema

• Major Interactions

potassium; angiotensin enzyme inhibitors

• MOA

ACE inhibition prevents the conversion of angiotensin I to angiotensin II, which is a potent vasoconstrictor. Decreased angiotensin II leads to decreased vasopressor activity and decreased aldosterone secretion

• Omeprazole

Answer

• Prilosec

• Gastric Acid Secretion Inhibitor (PPI)
• GERD; peptic ulcer; gastric ulcer; duodenum ulcer; erosive esophagitis

• 20 - 120 mg
• Oral route

• Side effects 2 / 3

angina; CV event risk; increased BP; palpitations; peripheral edema

• MOA

Omeprazole is a substituted benzimidazole and markedly inhibits basal and stimulated gastric acid secretion

• Metformin

Answer

• Glucophage

• Antidiabetic
• Oral
• Type 2 diabetes mellitus
• 500-1200mg

• Side effects

Cobalamin deficiency; GI upset; malabsorption syndrome; vomiting; asthenia; headache; lactic acidosis; hepatitis

• Major interactions

diabetic ketoacidosis; severe renal impairment

• MOA

decreases hepatic glucose production & intestinal absorption; improves insulin sensitivity

• Amlodipine

Answer

• Norvasc

• Antiaginal / Antihypertensive
• Oral
• Coronary arteriosclerosis; hypertension; stable angina, chronic; variant angina
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