NUR 162 Test 1 Antipsychotics
- Regarding antipsychotic use, which of the following side effects or side effect profiles is
most likely to be seen?
Answer Tardive Dyskinesia
Rationale Tardive dyskinesia is a common extrapyramidal side effect seen in pa- tients with long-term treatment. Lip-smacking is a type of tardive dyskinesia seen in patients taking these drugs.
- Which of the following diseases or disorder is most commonly associated with antipsychotic
use? (primary use)
Answer Schizophrenia
Rationale Antipsychotic drugs are primarily indicated for schizophrenia to treat its positive symptoms. Antipsychotics are also indicated for psychosis and mania.
- Which of the following diseases or disorder is most commonly associated with Fluphenazine
antipsychotic use?
Answer Tourette's Syndrome
Rationale Fluphenazine is used to treat Tourette's syndrome, an inherited disease characterized by motor and phonic tics
- What is true regarding antipsychotics?
Answer Lipid-soluble agents.
Rationale Antipsychotics are highly lipid-soluble and are stored in the body fat.They are very slowly removed from the body and are considered to have a long half-life.
- Regarding antipsychotic use, which of the following side effects is most likely seen? 1 / 2
Answer Alpha-1 Antagonist ("Afro 1 Wand Ant-toga)
Rationale These drugs display alpha 1 blockade effects, sometimes leading to hypotension.
- Which of the following is a side effect most likely to be seen associated with dry mouth?
Answer Anticholinergic
(Ant-tie-cola)
Rationale Antipsychotics drugs also block cholinergic receptors, leading to antimus- carinic effects. Patients can suffer from anticholinergic effects, such as dry mouth and constipation.
- Which is true regarding the MOA of antipsychotics?
Answer Block dopamine recep- tors ("Blocking Doberman Receptors")
Rationale Antipsychotic drugs block dopamine D2 receptors in the mesolimbic and mesocortical areas of the CNS. This leads to an increase of the intracellular concentration of the second messenger cyclic adenosine monophosphate (cAMP).
- Which of the following is a side effect most likely to be seen w/ antipsy- chotics?
Answer Galactorrhea
("Lactating and Pumping Breast milk")
Rationale Galactorrhea is an endocrine side effect r/t dopamine antagonism. Pa- tients typically have spontaneous outflow of milk from the breasts due to hyperpro- lactinemia stemming from dopamine antagonism.
- Which of the following best reflects the time course for the onset of tardive dyskinesia or
Parkinson's like symptoms associated with the use of high potency antipsychotic drugs?
Answer
- / 2