NUR 406 Autoimmune
- HLA system (human leukocyte antigen system)
Answer Normal ability of immune system to differentiate self from non-self belongs what system?
- HLA system (Human Leukocyte Antigen System)
Answer Need 80% match of this for transplant
is encoded by major histocompatibility genes (MHC) In order to elicit a T-system response, antigen must be processed & presented on surface of phagocytic cell (Macrophage with MHC antigens) Dual recognition system considered a security system T and B system with own recognition systems
- to create and immune response (dual recognition)
Answer the B and T cells work together to
- upregulated
Answer HLA genes are in autoimmune illnesses,multiple cy- tokines activated,inflammatory process
- chemical messengers that activate the inflammatory response
Answer what are cytokines?
- blocking cytokines
Answer what has been treatment approach for many auto-immune diseases
- infliximab 1 / 2
Answer
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Tumor necrosis factor alpha as cytokine, so they developed
- self tolerance
Answer Disrupted through misrecognition by B or T cell such as a virus or drug complexed to carrier molecule or cytokine
DNA usually in nucleus or mitochondria so if DNA outside these areas, immune system identifies it as foreign and attacks it
- B cell alteration theory
Answer B cell immunity requires support of helper T cells therefore auto AB also require this process
For some reason the T system cannot suppress the B cell changes New research focusing on boosting natural protective cells of immune system
- T cell receptor alteration
Answer T cells do not recognize the need to shut off as in a normal response resulting in an autoimmune disease
- 2 T helpers
- supressor
Answer
Answer what is the normal ratio of T help to suppressor cells?
- T cells
Answer HIV has decreased cells and suppressor cells predominate causing various diseases due to immunosuppression
- overactive T helper cells
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