NUR 4445 Immune Dysfunction
1.
"foreign substances that trigger the immune response" Antigens
- primary immune cells
leukocytes (WBC)
- wbc stored in , spleen, bone marrow
thymus
- two types of wbc
- (eat invadors)
- (develop antibodies)
phagocytes, lymphocytes
- lymphocytes
-b-cells
produce
-t-cells
destroy 1 / 3
antibodies, antigens
6.
group of proteins that assist in killing invading organisms
complement
- immune funtion is in newborns
poor
- newborn
• Neutrophils, monocytes, macrophages are present but not functioning • Lymphocytes are produced in-utero, thymus is fully functional at birth, how- ever, and cells are not very efficient
• Complement factors are 10-80% of an adult
well, t, b
- •Immunoglobulin levels newborn
-IgG - crosses placenta, present at birth, then around 7-8 months, mature levels ~ 8 years -IgM - low at birth, increase at 1 week of age, mature level by -IgA & IgE - present at birth, production begins at 2 weeks, mature levels ~ 6 years
-IgD - little information known, co-expressed with IgM 2 / 3
declines, 1 year, not
- immunodeficiency disorders
-primary
digeorge syndrome, wiskott-aldrich syndrome, severe combines immunodeficiency
-aquired
HIV
- disorders
-juvenile idiopathis arthritis
-systemic lupus erythematosus
autoimmune
- allergic reactions
-meds -food
-
environment
- cancers of the immune system
-
-
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