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NURS 617 PHARM EXAM 1 (JEAN GENZALE
PHARMACOTHERAPEUTICS FOR ADVANCED
NURSING PRACTICE ) ACTUAL EXAM
QUESTIONS AND CORRECT ANSWERS
AGRADE
RATED
Which combination of drugs has the potential of producing a harmful inhibitory drug interaction ?a . Concurrent use of aspirin and warfarin for anticoagulation .b . Protamine giver after heparin - induced excessive bleeding c . Injecting NPH insulin into a bottle of regular insulin d . Concurrent use of aspirin and codeine for pain relief . - ANSWER-c . Injecting NPH insulin into a bottle of regular insulin
An excessive dose of meperidine ( Demerol ) causing respiratory depression and sedation can be classified as what type of adverse drug reaction ?a . Delayed ADR b . Idiosyncratic ADR 1 / 4
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2 c . Cumulative ADR d . Intrinsic ADR - ANSWER-d . Intrinsic ADR
Which of the following factors has the LEAST effect on the rate or extent of drug excretion by the kidney ?a . Renal blood flow b . Urinary pH c . Advanced age ( > 65 ) d . Route of administration - ANSWER-d . Route of administration
- drug half - life can be defined as
- The total time a drug is present in the serum ( or tissue ) for it to produce any clinical effects (
a . The time it takes , after a drug is administered , to reach an effective serum ( or tissue ) concentration that is capable of producing a minimal clinical response b . The time it takes , after a drug is administered , to reach an effective serum ( or tissue ) concentration capable of producing a maximal clinical response
minimal or max ) d . The time it takes , after a drug is administered , to reach an effective serum concentration equal to one half of what it was at its peak concentration - ANSWER-d . The time it takes , after a drug is administered , to reach an effective serum concentration equal to one half of what it was at its peak concentration 2 / 4
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In the pregnant patient a . Gastric emptying is increased and speed absorption of drugs from the small intestine b . Gastric acid levels are lower than normal c . Water - soluble drugs will have a smaller distribution and be more concentrated d . The placenta contains enzymes that can help metabolize drugs - ANSWER-d . The placenta contains enzymes that can help metabolize drugs
The therapeutic effect we achieve by intentionally using a combination of two or three antihypertensive medications simultaneously to treat hypertension utilizes the principles of a . Potentiative pharmacokinetic drug - drug interactions b . Potentiative pharmacodynamic drug - drug interactions c . Competition for protein binding sites d . Direct physiochemical drug - drug interaction - ANSWER-b . Potentiative pharmacodynamic drug - drug interactions
Pharmacodynamics can be defined as a . The study of how genes affect a person's response to drugs b . The mechanisms by which drug molecules influence target cells , or cellular environments c . The mechanisms by which the body handles ( processes ) drugs 3 / 4
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4 d . The study of harmful or toxic effects of drugs and their molecular targets - ANSWER-b . The mechanisms by which drug molecules influence target cells , or cellular environments
Some medications work by interacting directly with a specific enzyme to decrease its action.Which scenario is an example of a drug enzyme interaction?
- Stool softeners altering the surface of hard stool allowing water from the colonic lumen to
enter the stool, making it softer b . Activated charcoal binding to orally ingested drugs and toxin , preventing their absorption c . Digoxin binging to NA / K ATPase inhibiting the exit of sodium ions from cardiac muscle cells and enhancing the entry of calcium ions into the cell d . Antacids blocking the secretion of acid by gastric cells to reduce acidity in the stomach - ANSWER-c . Digoxin binging to NA / K ATPase inhibiting the exit of sodium ions from cardiac muscle cells and enhancing the entry of calcium ions into the cell
Which list of drug formulations are in the correct order based on the relative speeds of their absorption from fastest to slowest ? a . Elixir , capsule , enteric coated tablet , powder b . Suspension , elixir , syrup , aerosol c . Syrup , elixir , powder , tablet d . Tablet , capsule , powder , aerosol - ANSWER-c . Syrup , elixir , powder , tablet
Which statement is true concerning the relationship between absorption and the site of drug administration ?
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