Page 1 of 140
1
NURS 617 PHARM EXAM 2 LATEST VERSIONS
(JEAN GENZALE PHARMACOTHERAPEUTICS
FOR ADVANCED NURSING PRACTICE) ACTUAL
EXAM QUESTIONS AND CORRECT ANSWERS
AGRADE
RATED
NURS 617 PHARM EXAM A
You are prescribing for a patient with severe hepatic cirrhosis and very low serum albumin .Which statement correctly describes how these conditions would affect serum drug levels ?a . Highly protein - bound drugs may have difficult to predict serum levels of free drug b . Administration of a prodrug may have a faster than normal time to onset of action c . A fat soluble drug may have a faster than normal rate of conversion to a water soluble form d . Weakly protein bound drugs will be metabolized at a faster than normal rate - ANSWER-a .Highly protein - bound drugs may have difficult to predict serum levels of free drug
The absorption of a medication from the intestinal mucosa a . Is affected by the degree of ionization of the drug b . Requires energy to move from the concentration gradient c . Is rapid , equivalent to IV administration 1 / 4
Page 2 of 140
2 d . Is increased in patients with diarrhea due to rapid transit time - ANSWER-a . Is affected by the degree of ionization of the drug
What type of drug - drug interaction do you have to worry about when administering cholestyramine ( questran ) together with other orally administered drugs ?a . Potentiative pharmacodynamics b . Inhibitory pharmacodynamics c . Inhibitory pharmacokinetic d . Potentiative pharmacokinetic - ANSWER-c . Inhibitory pharmacokinetic
Which of the following agents can be used for both nicotine withdrawal as well as an antidepressant ?a . Amitriptyline b . Bupropion ( Zyban ) c . Nicotine transdermal systems d . Varenicline ( Chantix ) - ANSWER-b . Bupropion ( Zyban )
Which of the following is an advantage of using nicotine products as pharmacologic therapy for nicotine . withdrawal ?a . Dosage is the same for all patients 2 / 4
Page 3 of 140
3 b . There is a low relapse rate with all forms of nicotine replacement c . Patients may use the products for over 6 months d . Products are available over the counter - ANSWER-d . Products are available over the counter
Which drug combination could be potentiative , necessitating monitoring of serum drug levels ?a . Carbamazepine ( tegretol ) + valproic acid ( depakene ) b . Phenobarbital + metoclopramide ( Reglan ) c . Ethosuximide ( Zarotin ) + omeprazole ( Prilosec ) d . Topiramate ( Topamax ) + sumatritan ( Imitrex ) - ANSWER-a . Carbamazepine ( tegretol ) + valproic acid ( depakene )
Which of the following is most likely to produce an inhibitory , pharmacokinetic drug - drug interaction ?a . The proton pump inhibitor , Lansoprazole ( prevacid ) b . The h - 2 blocker , famotidine ( Pepcid ) c . The barrier paste , sucralfate ( Carafate ) d . The prostaglandin analog , misoprostel ( cytotec ) - ANSWER-c . The barrier paste , sucralfate
- Carafate )
- / 4
Page 4 of 140
4 Which of the following atypical antipsychotics does not cause weight gain , and may even result in weight loss ?a . Ziprasidone ( Geodon ) b . Risperidone ( Risperdal ) c . Olanzapine ( zyprexa ) d . Clozapine ( clozaril ) - ANSWER-a . Ziprasidone ( Geodon )
A middle - aged executive who experienced insomnia with 2 different SSRIs . Which alternative therapy could relieve insomnia and depression ?a . MAOI b . SNRI c . TCA d . Benzodiazepine - ANSWER-c . TCA
Inhalational formulations of a drug are absorbed very quickly because a . There is small alveolar membrane surface area b . There are no natural defenses against inhaled particles c . They will be absorbed equally from both the lungs and the upper digestive tract d . Of the enormous blood supply at the alveolar capillary membrane - ANSWER-d . Of the enormous blood supply at the alveolar capillary membrane
- / 4