ONSONCC CHEMOTHERAP Y

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ONS/ONCC CHEMOTHERAP Y

IMMUNOTHERAPY CERTIF ICATE

EXAM WITH 100% CORRECT

ANSWERS

Question 1: 3 major phases of cell division:

CORRECT ANSWER : Interphase, Mitotic phase,

Cytokinesis

Question 2: 3 steps of interphase:

CORRECT ANSWER : First growth phase (G1),

Synthesis phase (S phase), Second growth phase (G2)

Question 3: 4 phases of mitosis:

CORRECT ANSWER : Prophase, Metaphase, Anaphase,

Telophase

Question 4: Innate immunity: CORRECT ANSWER : Non-specific response, either:

• Barrier (skin, mucous membranes, flora of skin/gut)

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• Cellular components (phagocytes, natural killer cells,

granulocytes, macrophages)

Question 5: Adaptive immunity:

CORRECT ANSWER : Follows innate immunity if

unsuccessful. Memory immunity, including:

• Humoral immunity (production of antibodies or

immunoglobulins)

• Cell-mediated immunity (dependent upon T cells)
• Regulatory T-cells (prevent autoimmune reactions and

limit inflammatory responses)

Question 6: Define mutations

CORRECT ANSWER : Variations in the nucleotide

sequence of a gene

Question 7: 3 main goals of treatment:

CORRECT ANSWER : Cure, Control, Palliation

Question 8: Define neoadjuvant therapy

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CORRECT ANSWER : Treatment is given prior to

surgery to shrink the tumor

Question 9: Define adjuvant therapy

CORRECT ANSWER : Additional cancer treatment

given after the primary treatment to lower the risk that the cancer reoccurs

Question 10: Define conditioning/preparative therapy

CORRECT ANSWER : Treatments used to prepare a

patient for stem cell transplantation

Question 11: 2 types of conditioning therapies:

CORRECT ANSWER : Myeloablative,

Nonmyeloablative

Question 12: Define dose density

CORRECT ANSWER : Drug dose per unit of time

Question 13: Define dose intensity

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CORRECT ANSWER : Amount of drug delivered over

time

Question 14: How is relative dose intensity (RDI)

calculated?

CORRECT ANSWER : By comparing the dose that the

patient ACTUALLY received to the planned dose of the standard regimen

Question 15: How do alkylating agents work?

CORRECT ANSWER : By causing a break in the DNA

helix strand, interfering with DNA replication and causing cell death

Question 16: 3 subcategories of alkylating agents:

CORRECT ANSWER :

• Nitrogen mustards
• Platinum-based agents (do not possess an alkyl group

but still termed alkylating agents as they work similarly)

• Nitrosoureas