Oral Pathology 7th Edition Regezi Test Bank

Oral Pathology 7th Edition Regezi Test Bank

Chapter 1: Vesiculobullous Diseases

Test Bank

MULTIPLE CHOICE

• Intercellular deposits of IgG are consistently found in oral epithelium in which of the

following?

• Cicatricial pemphigoid
• Lichen planus
• Pemphigus vulgaris
• Stevens-Johnson syndrome
• Aphthous ulcers

ANS: C REF: Chap 1 (Pemphigus vulgaris/Etiology and pathogenesis), p 11

• A patient seeks help for recurrent palatal pain. She presents with multiple punctate ulcers in

the hard palate that were preceded by tiny blisters. Her lesions typically heal in about 2 weeks

and reappear during stressful times. She has:

• Aphthous ulcers
• Recurrent primary herpes
• Recurrent secondary herpes
• Erythema multiforme
• Discoid lupus

ANS: C REF: Chap 1 (Herpes simplex infection/Pathogenesis), pp 1-3

• All but one of the followinT

gE arS eT cB onA taN gK ioS uE s aL nL dE thR u.s C arO e M potential occupational hazards to the dentist and dental hygienist. Choose the noncontagious condition.

• Oral histoplasmosis
• Pemphigus vulgaris
• Cold sores
• Primary herpes
• Oral chancre

ANS: B REF: Chap 1 (Pemphigus vulgaris), pp 11-15

• A 55-year-old man presents with a single deep indurated crateriform lesion of the posterior

lateral border of the tongue. It is asymptomatic. This could be all of the following except:

• Squamous cell carcinoma
• Chronic traumatic ulcer
• Secondary herpes
• Syphilis
• Histoplasmosis

ANS: C REF: Chap 1 (Herpes simplex infection/Box 1-2), p 4

• Bilateral buccal mucosal white lesions would be expected in all the following except:
• Cannon’s disease (white sponge nevus)
• Witkop’s disease (HBID)
• Secondary herpes zoster 1 / 4

• Leukoedema
• Cheek chewing

ANS: C REF: Chap 1 (Varicella-zoster infection), pp 6-8

• Which of the following vesiculobullous disorders is nonhereditary and occurs almost

exclusively on the skin?

• Pemphigus vulgaris
• Cicatricial pemphigoid
• Epidermolysis bullosa
• Lupus erythematosus
• Bullous pemphigoid

ANS: E REF: Chap 1 (Bullous pemphigoid), pp 17-18

• Which of the following conditions exhibits subepithelial separation microscopically?
• Pemphigus vulgaris
• Mucous membrane pemphigoid
• Aphthous stomatitis
• Secondary herpes simplex
• None of the above

ANS: B

REF: Chap 1 (Mucous membrane pemphigoid/Histopathology and immunopathology), pp 16-17

• The palate and maxillary ridge of a 56-year-old woman contain multiple flat ulcers of 8

weeks’ duration. She has a positive Nikolsky sign and has no evidence of skin or lip lesions.Which of the following sho T u E ld S r T ec B e A iv N e K se S ri E o L us L c E o R ns .id C e O ra M tion in the clinical differential diagnosis?

• Pemphigus vulgaris
• Herpangina
• Lichen planus
• Aphthous stomatitis
• Herpes simplex infection

ANS: A REF: Chap 1 (Pemphigus vulgaris), pp 11-15

• A 22-year-old woman complains of mildly painful ulcers in her hard palate. The ulcers are

multiple and confluent. A similar condition has been noted in the patient on two previous

occasions. This is most likely:

• Trauma
• Herpangina
• Candidiasis
• Riga-Fede disease
• Secondary herpes

ANS: E REF: Chap 1 (Secondary, or recurrent, herpes simplex infection), pp 3-4

• Cytologic examination can be diagnostic of which of the following diseases?
• Herpes simplex
• Recurrent aphthae
• Mucous membrane pemphigoid 2 / 4

• Erosive lichen planus
• Frictional hyperkeratosis

ANS: A REF: Chap 1 (Herpes simplex infection/Histopathology), p 5

11. The Tzanck cells in pemphigus vulgaris result from:

• Acantholysis
• Acanthosis
• Intercellular edema
• Intracellular edema
• Mucous extravasation

ANS: A

REF: Chap 1 (Pemphigus vulgaris/Histopathology and immunopathology), pp 11-14

• Site specificity is a characteristic clinical feature of which of the following conditions when it

occurs intraorally?

• Syphilis
• Candidiasis
• Histoplasmosis
• Intraoral tuberculosis
• Secondary herpes simplex infection

ANS: E REF: Chap 1 (Secondary, or recurrent, herpes simplex infection), p 4

13. Herpes simplex infections are most rationally treated with:

• Lysine
• Topical clobetasol
• Acyclovir

• Topically applied tetracycline
• Prednisone

ANS: C REF: Chap 1 (Herpes simplex infection/Treatment), p 6

• A middle-aged man developed multiple flat ulcers in his palate, tongue, and buccal mucosa.

The lesions measured approximately 1 cm in diameter and were preceded briefly by bullae.The lesions have been persistent for 6 weeks. He has no skin, eye, or genital lesions. Biopsy

shows acantholysis with intraepithelial separation. He most likely has:

• Erythema multiforme
• Discoid lupus erythematosus
• Primary herpes simplex infection
• Mucous membrane pemphigoid
• None of the above

ANS: E

REF: Chap 1 (Herpes simplex infection/Mucous membrane pemphigoid), pp 1-6 |Chap 1 (Herpes simplex infection/Mucous membrane pemphigoid), pp 15-17 | Chap 2 (Erythema multiforme), pp 43-46 | Chap 3 (Discoid lupus erythematosus), p 102

• Biopsy confirmation of mucous membrane pemphigoid can be made by which of the

following?

• Direct immunofluorescence 3 / 4

• Fite stain of tissue section
• Determination of serum antinuclear antibodies (ANAs)
• Observed response to trial dose of acyclovir
• None of the above

ANS: A REF: Chap 1 p 14

• The bullous eruption of attached gingiva mediated by autoantibodies directed against

basement membrane antigens is known as:

• Pemphigus vulgaris
• Lupus erythematosus
• Erythema multiforme
• Behçet’s syndrome
• None of the above

ANS: E

REF: Chap 1 (Pemphigus vulgaris), pp 11-15 | Chap 2 (Erythema multiforme/Behçet’s syndrome), pp 42-46 | Chap 3 (Lupus erythematosus), pp 102-104

• Generally, corticosteroids are contraindicated in the treatment of which of the following

conditions?

• Chronic traumatic ulcers
• Pemphigus vulgaris
• Herpetiform aphthous ulcers
• Hand-foot-and-mouth disease
• Mucous membrane pemphigoid

ANS: D REF:

T C E ha S p T 1 B (H A a N n K d- S fo E ot L -a L nd E - R m .ou C th O d M isease/Treatment), p 9

• Lesions found in the buccal mucosa, known as Koplik’s spots, are first signs of which of the

following?

• Erythema multiforme
• Herpangina
• Rubeola
• Varicella
• Acute lupus erythematosus

ANS: C REF: Chap 1 (Measles/Clinical features), p 10

• Systemic corticosteroids can affect many metabolic processes. Which of the following effects

of prednisone is regarded as therapeutic when prescribed for patients with pemphigus vulgaris and mucous membrane pemphigoid?

• Gluconeogenesis
• Potentiation of vasopressors
• Suppression of pituitary-adrenal axis
• Sodium resorption
• Immunosuppression

ANS: E

REF: Chap 1 (Pemphigus vulgaris/Treatment and prognosis/Box 1-6), pp 14-15

• Which of the following is important in the clinical efficacy of a topical corticosteroid?
• / 4