CPPS 304
Receptor correct answerMacromolecule whose biological function changes when a drug binds to it What are the link between chemical actions and biological function? correct answerReceptors Emax correct answermaximum effect of a drug What happens when Emax is reached? correct answerEmax occurs when all receptors are bound What is in indication that spare receptors are present? correct answerWhen Emax is reached before all receptors are bound Agonist correct answerhas affinity for a receptor as well as intrinsic activity at the receptor Antagonist correct answerhas affinity for a receptor but no intrinsic activity at the receptor partial agonist correct answerhas affinity for a receptor but lacks the full intrinsic activity of an agonist inverse agonist correct answerbinds to a constitutively active receptor and inactivates it affinity correct answerthe propensity of a ligand to bind to a receptor high affinity = correct answerbinds readily to a receptor low affinity = correct answerspends less time bound to a given receptor intrinsic activity correct answerthe action carried out by the ligand while it is bound to a receptor 1 / 2
Kd correct answerdissociation constant (affinity of a drug for a receptor) What does the value of Kd signify? correct answermeasures the propensity of a drug to release (dissociate) from a receptor What does a high Kd mean? correct answerdrug readily dissociates from its receptor What does a low Kd mean? correct answersuggests high affinity for its receptor If a patient were to overdose on a reversible antagonist, what could you do? correct answerAdd more agonist Irreversible or Non-Competitive Antagonists correct answerbind to receptor for life Reversible or Competitive Antagonists correct answerbind and release from a receptor and are in a constant state of flux True or False, increasing the concentration of agonist will overcome the effects of an irreversible antagonist. correct answerFalse What are the four types of receptors? correct answerIon channel, G-protein coupled, Coupled to enzymes, Intracellular What type of receptor involves Acetylcholine? correct answerIon channel What is the fastest type of receptor? correct answerIon channel What type of receptor involves adrenergics like epinephrine? correct answerG-protein coupled
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