NR 546 Neurotransmitter Table Neurotransmitter Table
- To be completed throughout course and submitted in Week 8*
Neuro transmitter Receptor Subtype Location/Function/Effects symptoms of excess or deficit if applicable Distribution
(ie: CNS/PNS, GI,
vascular) Drug classes that target this neurotransmitter or receptor Specific medications that target this neurotransmitter or receptor Glutamate AMPA Ligand-gated ion channels, modulates cell excitability by allowing the flow of calcium and sodium ions into the cell.
Located at the CNS in neurons and glia.
CNS NMDA
Glutamate antagonist Barbiturates Antiepileptics Parampanel Memantine PCP Ketamine Dextromethorphan Dextromethadone
Excess has resulted in schizophrenia, epilepsy, and mania
NMDA Ligand-gated ion channels, strengthens synapses and involved in strong memory formation.
Excess is associated with memory and learning impairments, psychosis, and excitotoxic brain injury CNS NMDA receptor antagonist Antipsychotics Loop Diuretics Opiates Antidepressants Memantine Amantadine Ketamine Dextromethorphan Methadone Dextropropoxyphene Ketobemidone Furosemide Haldol Tramadol GABA GABA a Ligand-gated ion channels Functions as post synaptic inhibition by CI-influx
Lack of GABA leads to the conditions like epilepsy, seizures, CNS Limbic system Striatum Medulla Spinal Cord Pancreas Benzodiazepines Hypnotics Neuroactive steroids Lorazepam Clonazepam Alprazolam Zolpidem Zopiclone Zaleplon 1 / 2
and mood disorders.
Excess GABA leads to hypersomnia.Sedative and analgesic properties Allopregnanolone GABA b G-Protein Linked Functions as pre-synaptic inhibition by lowering calcium ion entry while post-synaptic inhibitions by increasing potassium ion permeability
Reduces fear, anxiety, and convulsions CNS/PNS GABA-b receptor agonists Antispastic anesthetics Baclofen Arbaclofen Placarbil Propofol Serotonin 5HT 5HT 1a Located on GABA interneurons in the prefrontal cortex
5HT1A receptors can promote the release of other NTs.
5HT1A receptors are always inhibitory, but they are very frequently localized upon postsynaptic GABA neurons, which means that the net downstream effect in this case is excitatory Cerebral Cortex Midbrain raphe Hippocampus Amygdala Basal Ganglia Thalamus SSRIs, SNRIs, SGAs, FGAs, MAOIs, TCAs, Mood stabilizers Buspirone Clozapine Trazodone Lurasidone Quetiapine Valproate Lithium Brexpiprazole Aripiprazole Cariprazine Vortioxetene
Excess: Psychosis, mood
imbalance, anxiety
5HT 1B Autoreceptor located on the CNS Antidepressants SGAs Asenapine
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