UNE BioChem 1005 Final Exam Questions

UNE BioChem 1005 Final Exam 2024/2025 Questions with Complete Solutions Somatostatin reduces the secretion of both glucagon and insulin through which of the following mechanisms?

• Somatostatin activates an activator G-protein
• Somatostatin activates MAPK cascade
• Somatostatin activates an inhibitory G-protein
• Somatostatin uses Ca+2 as a downstream signal - Correct Answer c. Somatostatin activates an

inhibitory G-protein Insulin mediated glucose uptake by muscle and adipose tissue is a result of which of the following mechanisms?

• Translocation of GLUT 4 receptors to the cell surface
• Translocation of GLUT 1 (Na+/K+ symporter) to the cell surface
• Passive diffusion
• Activation of protein kinase A - Correct Answer a. Translocation of GLUT 4 receptors to the cell surface

The alanine - glucose cycle is primarily used for which of the following purposes?

• To move ammonia from skeletal muscle to the liver
• To generate ATP for the skeletal muscle
• To move glucose from the skeletal muscle to the liver
• To move alanine from the liver to the skeletal muscle - Correct Answer a. To move ammonia from

skeletal muscle to the liver Which statement best illustrates an example of post translational gene regulation?

• Protein kinase A mediated phosphorylation of glycogen phosphorylase 1 / 2

• Cortisol binds a cytosolic receptor, translocates to the nucleus and binds a GRE
• Iron binding the iron response elements binding protein (IRE_BP) allowing for translation of ferritin

mRNA

• DNA histone associations leading to super-coiling of DNA - Correct Answer a. Protein kinase A

mediated phosphorylation of glycogen phosphorylase Which of the following hormones is released from the liver in response to increased levels of growth hormone?

• Cortisol
• Thyroid hormone
• Somatostatin
• Insulin-like growth factor (IGF) - Correct Answer d. Insulin-like growth factor (IGF)

Autophagy is process involves degradation of protein. Under conditions of high energy (HIGH ATP) which of the following is true regarding regulation of this process?

• Akt is inactive
• AMPK is actice and phosphorylates TSC1/TSC2 Complex
• mTOR is activated
• Rheb is bound to GDP - Correct Answer c. mTOR is activated

Synthesis of which of the following lipoproteins would be elevated after a carbohydrate rich meal?

• HDL
• Chylomicrons
• LDL
• VLDL - Correct Answer d. VLDL
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