WCU 370 PATHOPHYSIOLOGY FINAL EXAM

WCU 370 PATHOPHYSIOLOGY FINAL EXAM

TESTBNK QUESTIONS AND CORRECT

DETAILED ANSWERS AGRADE

RATED

Which is a pathophysiologic change that is consistent with Alzheimer disease? (Select all that apply)

• Amyloid plaques
• Epileptogenic focus
• Focal cerebral infarct
• Neurofibrillary tangles
• Abnormal serotonin system - ANSWER✔✔a. Amyloid plaques
• Neurofibrillary tangles

Amyloid plaques and neurofibrillary tangles occur in the brains of Alzheimer patients and are found at autopsy. Neural thread proteins (tau protein) have a normal function and stabilize microtubules. In Alzheimer disease, they are chemically altered and twist into paired helical filaments known as neurofibrillary tangles. Epileptogenic focus is associated with seizure disorder. Focal cerebral infarct is a stroke occurring in a localized area of the brain. Abnormalities in the cholinergic system are associated with Alzheimer disease; serotonin abnormalities are found in depression. 1 / 4

Which statement regarding chronic myeloid leukemia (CML) is a true statement?

• It is not seen in children.
• It represents 30% of all cases of leukemia.
• The average age of onset is older than 70 years.
• Affected persons carry the Philadelphia chromosome. - ANSWER✔✔d. Affected

persons carry the Philadelphia chromosome.

Philadelphia chromosome occurs in this leukemia. CML occurs occasionally in children and adolescents. CML represents approximately 15% of all cases of leukemia in the US. The average age of onset is between 40-50 years.Which term is used to describe an excess of red blood cells?

• Anemia
• Polycythemia
• Pancytopenia
• Granulocytopenia - ANSWER✔✔b. Polycythemia

• Polycythemia is an excess of red blood cells.
• Anemia is a deficiency of red blood cells.
• Pancytopenia is a decrease in red blood cells, white blood cells, and platelets.
• Granulocytopenia is a decrease in platelets

It is true that acute lymphoid leukemia (ALL) is 2 / 4

• Incurable
• More curable in adults
• Primarily diagnosed in children
• Generally seen in adults older than 70 years - ANSWER✔✔c. Primarily diagnosed in

children

ALL is primarily a disorder occurring in children. ALL is highly curable in children, less so in adults. Peak incidence is between ages 3-7 years of age. A second rise occurs in middle age An enlarged thyroid gland produces a colloid goiter when

• Lack of iodine prevents formation of thyroid-stimulating hormone without stopping T4

and T3 production

• Lack of iodine prevents T4 and T3 but without stopping thyroglobulin formation
• Excessive iodine suppresses thyroid-stimulating hormone, T4, and T3 formation
• Dietary iodine is insufficient and replaced with iodized salt - ANSWER✔✔b. Lack of

iodine prevents T4 and T3 but without stopping thyroglobulin formation Which is a modifiable risk factor for prevention of atherosclerosis?

• Smoking
• Genetics
• Gender
• Age - ANSWER✔✔a. Smoking 3 / 4

What physiologic abnormality is characteristic of emphysema?

• Collapse of the proximal airways
• Trapping of air in the distal air sacs
• Widespread occurrence of bronchial plugs
• Extensive inflammation of the lower airways - ANSWER✔✔b. Trapping of air in the

distal air sacs Which condition constitutes an emergency situation?

• Phimosis
• Hydrocele
• Epididymitis
• Testicular torsion - ANSWER✔✔d. Testicular torsion

Which term is used to describe the histologic characterization of tumor cells?

• Staging
• Grading
• Cachexia
• Angiogenesis - ANSWER✔✔b. Grading

Which is a risk factor associated with hypertension? (Select all that apply.)

• Age
• Caucasian race
• African-American race
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