NR-565 Advanced Pharmacology Fundamentals
Week 5 Quiz
first line drug for hyperthyroidism
Correct Answer:
Methimazole (Tapazole)
MOA of Methimazole
Correct Answer:
inhibit synthesis of T4/3, prevents oxidation of iodine, prevents iodinated tyrosine's from coupling
The most dangerous adverse effect of Methimazole
Correct Answer:
agranulocytosis
Monitoring requirements for methimazole
Correct Answer:
CBC w/diff d/t risk of infection from low WBC
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Methimazole and pregnancy
Correct Answer:
Not safe in 1st trimester pregnancy-would use PTU (poorly crosses placenta)
What is the initial dose of Methimazole?
Correct Answer:
30-40mg
How long should a patient be treated with PTU or methimazole?
Correct Answer:
1-2 years
Patient education for methimazole must include:
Correct Answer:
report pregnancy while on it, agranulocytosis risk-report fever or sore throat immediately
Radioactive iodine can have delayed:
Correct Answer:
effect (can take 1-3 months)
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