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WGU 785 FINAL EXAM LATEST
WITH COMPLETE SOLUTI ON
Question : Hemophilia Pedigree - Father has hemophilia,
mother does not. What is the outcome for their kids?
Correct answer: His daughters would be carriers. This is
x-link recessive.
Question : Autosomal:
Dominant:
Autosomal: males and females equally affected.
Dominant: non-carrier parents
Correct answer: Autosomal: Dominant: Autosomal: males
and females equally affected. Dominant: non-carrier
parents
Question : polymerase chain reaction (PCR)
Correct answer: The process of copying DNA in the lab.
Uses Template DNA, Nucleotides (dNTPS), DNA Polymerase, and DNA primers.
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Question : 3 Steps of PCR
Correct answer: 1. Denaturation: DNA is heated to 95C to separate it.
2. Annealing: reaction is cooled to 50C; primers stick to
the DNA you want to copy and add DNA polymerase.
3. Elongation: reaction heated to 70C and DNA
polymerase, adding nucleotides building a new DNA strand.
Question : Base Excision Repair (BER)
Correct answer: How you repair a mutation. BER is used
to repair damage to a base caused by harmful molecules.You remove the base that is damaged and replace it. BER removes a single nucleotide DNA glycolsylase - sees damaged DNA and removes it.DNA polymerase-puts the right one back in while DNA ligase seals it.
Question : Mismatch repair (MMR) occurs during:
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Correct answer: replication. DNA polymerase proofreads
but sometimes a mismatch pair gets through. MMR removes a large section of the nucleotides from the new
DNA and DNA polymerase tries again. (Ex: C-T instead
of C-A)
Question : Mismatch Repair corrects what kind of DNA
damage?
Correct answer: When a base is mismatched due to errors
in replication. Such as G-T instead of G-C. DNA polymerase comes by and fixes it.
Question : What happens when DNA polymerase binds to
DNA to make RNA?
Correct answer: TRANSCRIPTION! DNA polymerase
takes the individual nucleotides and matches them to the parental sequences to ensure a correct pair. It must bind with RNA primer to work.
Question : What is needed for DNA replication?
Correct answer: DNA polymerase
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Question : Nonsense Mutation
Correct answer: Change in 1 nucleotide produces a STOP
codon Stop= nonsense because it is no more.
Question : Silent Mutation
Correct answer: Change in 1 nucleotide but codes for the
same amino acid. Silent= the change doesn't change the name of the protein
Question : Missense Mutation
Correct answer: Change in 1 nucleotide leads to a code
for a different amino acid. Missense = mistake was made.
Question : What happends during RNA splicing?
Correct answer: During RNA splicing introns are cut out,
the remaining exons are joined together.
Question : 5'ATG AGT CTC TCT 3'
Find the DNA template strand.