GMS 6552 Exam 1 Questions and Answers 100% Accurate
Question: which type of receptor most often utilizes second
messenger systems in its signaling?
Correct answer: GPCRs
Question: assume you have receptor antagonists that are able
to stop receptor signaling immediately. for which type of receptor would take the longest to see the effects of your drug at the cellular level?
Correct answer: nuclear receptors
Question: which type of receptor would having adequate
membrane permeability of an agonist be most critical?
Correct answer: nuclear receptors
Question: is it more likely for a GPCR agonist to bind near
the N- or C- terminus of the receptor?
Correct answer: N terminus
Question: is it more likely to find a GPCR bound to a G-
protein that is also bound to GTP or GDP?
Correct answer: GDP
Question: which protein ultimately is translocated from the
cytoplasm to the nucleus as a result of JAK signaling?
Correct answer: STAT
Question: where, in relation to the protein-coding region of a
gene, are the binding sites that become occupied by nuclear receptors?
Correct answer: upstream
Question: the levels of which second messenger would be
expected to increase following administration of nitroglycerin?
Correct answer: cGMP
Question: does TGF-beta treatment cause cells to grow more
or less in the soft agar assay?
Correct answer: more
Question: the latent TGF-beta peptide must be cleaved by
what protease in order to be activated?
Correct answer: plasmin
Question: in the TGF-beta pathway, which protein becomes
activated first upon binding of a ligand?
Correct answer: TGFBR2
Question: how many DNA binding domains do SMADs
have?
Correct answer: 1
Question: different SMAD complexes bind different genes,
which group of SMADs is responsible for this specifically?
Correct answer: R-Smads
Question: would it likely be most beneficial (for the tumor)
for an early tumor to up or down regulate the TGF-beta pathway?
Correct answer: down regulate
Question: would it likely be most beneficial (for the tumor)
for a large and well developed tumor to up or down regulate the TGF-beta pathway?
Correct answer: up-regulate
Question: where are the g-proteins located in relation to the
cellular membrane?
Correct answer: intracellularly
Question: which families of GPCRs contain disulfide bonds
between the first and second extracellular loops? select all that apply.
